Pro Nerve Growth Factor and Its Receptor p75NTR Activate Inflammatory Responses in Synovial Fibroblasts: A Novel Targetable Mechanism in Arthritis

We have recently provided new evidence for a role of p75NTR receptor and its preferential ligand proNGF in amplifying inflammatory responses in synovial mononuclear cells of chronic arthritis patients. In the present study, to better investigate how activation of the p75NTR/proNGF axis impacts synov...

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Detalles Bibliográficos
Autores principales: Farina, Luciapia, Minnone, Gaetana, Alivernini, Stefano, Caiello, Ivan, MacDonald, Lucy, Soligo, Marzia, Manni, Luigi, Tolusso, Barbara, Coppola, Simona, Zara, Erika, Conti, Libenzio Adrian, Aquilani, Angela, Magni-Manzoni, Silvia, Kurowska-Stolarska, Mariola, Gremese, Elisa, De Benedetti, Fabrizio, Bracci-Laudiero, Luisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931659/
https://www.ncbi.nlm.nih.gov/pubmed/35309353
http://dx.doi.org/10.3389/fimmu.2022.818630

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