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Diagnostic Value, Prognostic Value, and Immune Infiltration of LOX Family Members in Liver Cancer: Bioinformatic Analysis

BACKGROUND: Liver cancer (LC) is well known for its prevalence as well as its poor prognosis. The aberrant expression of lysyl oxidase (LOX) family is associated with liver cancer, but their function and prognostic value in LC remain largely unclear. This study aimed to explore the function and prog...

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Autores principales: Sun, Chenyu, Ma, Shaodi, Chen, Yue, Kim, Na Hyun, Kailas, Sujatha, Wang, Yichen, Gu, Wenchao, Chen, Yisheng, Tuason, John Pocholo W., Bhan, Chandur, Manem, Nikitha, Huang, Yuting, Cheng, Ce, Zhou, Zhen, Zhou, Qin, Zhu, Yanzhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931681/
https://www.ncbi.nlm.nih.gov/pubmed/35311155
http://dx.doi.org/10.3389/fonc.2022.843880
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author Sun, Chenyu
Ma, Shaodi
Chen, Yue
Kim, Na Hyun
Kailas, Sujatha
Wang, Yichen
Gu, Wenchao
Chen, Yisheng
Tuason, John Pocholo W.
Bhan, Chandur
Manem, Nikitha
Huang, Yuting
Cheng, Ce
Zhou, Zhen
Zhou, Qin
Zhu, Yanzhe
author_facet Sun, Chenyu
Ma, Shaodi
Chen, Yue
Kim, Na Hyun
Kailas, Sujatha
Wang, Yichen
Gu, Wenchao
Chen, Yisheng
Tuason, John Pocholo W.
Bhan, Chandur
Manem, Nikitha
Huang, Yuting
Cheng, Ce
Zhou, Zhen
Zhou, Qin
Zhu, Yanzhe
author_sort Sun, Chenyu
collection PubMed
description BACKGROUND: Liver cancer (LC) is well known for its prevalence as well as its poor prognosis. The aberrant expression of lysyl oxidase (LOX) family is associated with liver cancer, but their function and prognostic value in LC remain largely unclear. This study aimed to explore the function and prognostic value of LOX family in LC through bioinformatics analysis and meta-analysis. RESULTS: The expression levels of all LOX family members were significantly increased in LC. Area under the receiver operating characteristic curve (AUC) of LOXL2 was 0.946 with positive predictive value (PPV) of 0.994. LOX and LOXL3 were correlated with worse prognosis. Meta-analysis also validated effect of LOX on prognosis. Nomogram of these two genes and other predictors was also plotted. There was insufficient data from original studies to conduct meta-analysis on LOXL3. The functions of LOX family members in LC were mostly involved in extracellular and functions and structures. The expressions of LOX family members strongly correlated with various immune infiltrating cells and immunomodulators in LC. CONCLUSIONS: For LC patients, LOXL2 may be a potential diagnostic biomarker, while LOX and LOXL3 have potential prognostic and therapeutic values. Positive correlation between LOX family and infiltration of various immune cells and immunomodulators suggests the need for exploration of their roles in the tumor microenvironment and for potential immunotherapeutic to target LOX family proteins.
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spelling pubmed-89316812022-03-19 Diagnostic Value, Prognostic Value, and Immune Infiltration of LOX Family Members in Liver Cancer: Bioinformatic Analysis Sun, Chenyu Ma, Shaodi Chen, Yue Kim, Na Hyun Kailas, Sujatha Wang, Yichen Gu, Wenchao Chen, Yisheng Tuason, John Pocholo W. Bhan, Chandur Manem, Nikitha Huang, Yuting Cheng, Ce Zhou, Zhen Zhou, Qin Zhu, Yanzhe Front Oncol Oncology BACKGROUND: Liver cancer (LC) is well known for its prevalence as well as its poor prognosis. The aberrant expression of lysyl oxidase (LOX) family is associated with liver cancer, but their function and prognostic value in LC remain largely unclear. This study aimed to explore the function and prognostic value of LOX family in LC through bioinformatics analysis and meta-analysis. RESULTS: The expression levels of all LOX family members were significantly increased in LC. Area under the receiver operating characteristic curve (AUC) of LOXL2 was 0.946 with positive predictive value (PPV) of 0.994. LOX and LOXL3 were correlated with worse prognosis. Meta-analysis also validated effect of LOX on prognosis. Nomogram of these two genes and other predictors was also plotted. There was insufficient data from original studies to conduct meta-analysis on LOXL3. The functions of LOX family members in LC were mostly involved in extracellular and functions and structures. The expressions of LOX family members strongly correlated with various immune infiltrating cells and immunomodulators in LC. CONCLUSIONS: For LC patients, LOXL2 may be a potential diagnostic biomarker, while LOX and LOXL3 have potential prognostic and therapeutic values. Positive correlation between LOX family and infiltration of various immune cells and immunomodulators suggests the need for exploration of their roles in the tumor microenvironment and for potential immunotherapeutic to target LOX family proteins. Frontiers Media S.A. 2022-03-04 /pmc/articles/PMC8931681/ /pubmed/35311155 http://dx.doi.org/10.3389/fonc.2022.843880 Text en Copyright © 2022 Sun, Ma, Chen, Kim, Kailas, Wang, Gu, Chen, Tuason, Bhan, Manem, Huang, Cheng, Zhou, Zhou and Zhu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Sun, Chenyu
Ma, Shaodi
Chen, Yue
Kim, Na Hyun
Kailas, Sujatha
Wang, Yichen
Gu, Wenchao
Chen, Yisheng
Tuason, John Pocholo W.
Bhan, Chandur
Manem, Nikitha
Huang, Yuting
Cheng, Ce
Zhou, Zhen
Zhou, Qin
Zhu, Yanzhe
Diagnostic Value, Prognostic Value, and Immune Infiltration of LOX Family Members in Liver Cancer: Bioinformatic Analysis
title Diagnostic Value, Prognostic Value, and Immune Infiltration of LOX Family Members in Liver Cancer: Bioinformatic Analysis
title_full Diagnostic Value, Prognostic Value, and Immune Infiltration of LOX Family Members in Liver Cancer: Bioinformatic Analysis
title_fullStr Diagnostic Value, Prognostic Value, and Immune Infiltration of LOX Family Members in Liver Cancer: Bioinformatic Analysis
title_full_unstemmed Diagnostic Value, Prognostic Value, and Immune Infiltration of LOX Family Members in Liver Cancer: Bioinformatic Analysis
title_short Diagnostic Value, Prognostic Value, and Immune Infiltration of LOX Family Members in Liver Cancer: Bioinformatic Analysis
title_sort diagnostic value, prognostic value, and immune infiltration of lox family members in liver cancer: bioinformatic analysis
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931681/
https://www.ncbi.nlm.nih.gov/pubmed/35311155
http://dx.doi.org/10.3389/fonc.2022.843880
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