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Systematic Tracing of Susceptible Animals to SARS-CoV-2 by a Bioinformatics Framework
Since the outbreak of SARS-CoV-2 in 2019, the Chinese horseshoe bats were considered as a potential original host of SARS-CoV-2. In addition, cats, tigers, lions, mints, and ferrets were naturally or experimentally infected with SARS-CoV-2. For the surveillance and control of this highly infectious...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931700/ https://www.ncbi.nlm.nih.gov/pubmed/35308363 http://dx.doi.org/10.3389/fmicb.2022.781770 |
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author | Sun, Hailiang Wang, Ailan Wang, Lixia Wang, Bing Tian, Geng Yang, Jialiang Liao, Ming |
author_facet | Sun, Hailiang Wang, Ailan Wang, Lixia Wang, Bing Tian, Geng Yang, Jialiang Liao, Ming |
author_sort | Sun, Hailiang |
collection | PubMed |
description | Since the outbreak of SARS-CoV-2 in 2019, the Chinese horseshoe bats were considered as a potential original host of SARS-CoV-2. In addition, cats, tigers, lions, mints, and ferrets were naturally or experimentally infected with SARS-CoV-2. For the surveillance and control of this highly infectious disease, it is critical to trace susceptible animals and predict the consequence of potential mutations at the binding region of viral spike protein and host ACE2 protein. This study proposed a novel bioinformatics framework to systematically trace susceptible animals to SARS-CoV-2 and predict the binding affinity between susceptible animals’ mutated/un-mutated ACE2 receptors. As a result, we identified a few animals posing a potential risk of infection with SARS-CoV-2 using the docking analysis of ACE2 protein and viral spike protein. The binding affinity of some of these species is weaker than that of humans but more potent than that of Chinese horseshoe bats. We also found that a few point mutations in human ACE2 protein or viral spike protein could significantly enhance their binding affinity, posing an enormous potential threat to public health. The ancestors of the Omicron may evolve rapidly through the accumulation of mutations in infecting the host and jumped into human beings. These findings indicate that if the epidemic expands, there may be a human-animal-human transmission route, which will increase the difficulty of disease prevention and control. |
format | Online Article Text |
id | pubmed-8931700 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89317002022-03-19 Systematic Tracing of Susceptible Animals to SARS-CoV-2 by a Bioinformatics Framework Sun, Hailiang Wang, Ailan Wang, Lixia Wang, Bing Tian, Geng Yang, Jialiang Liao, Ming Front Microbiol Microbiology Since the outbreak of SARS-CoV-2 in 2019, the Chinese horseshoe bats were considered as a potential original host of SARS-CoV-2. In addition, cats, tigers, lions, mints, and ferrets were naturally or experimentally infected with SARS-CoV-2. For the surveillance and control of this highly infectious disease, it is critical to trace susceptible animals and predict the consequence of potential mutations at the binding region of viral spike protein and host ACE2 protein. This study proposed a novel bioinformatics framework to systematically trace susceptible animals to SARS-CoV-2 and predict the binding affinity between susceptible animals’ mutated/un-mutated ACE2 receptors. As a result, we identified a few animals posing a potential risk of infection with SARS-CoV-2 using the docking analysis of ACE2 protein and viral spike protein. The binding affinity of some of these species is weaker than that of humans but more potent than that of Chinese horseshoe bats. We also found that a few point mutations in human ACE2 protein or viral spike protein could significantly enhance their binding affinity, posing an enormous potential threat to public health. The ancestors of the Omicron may evolve rapidly through the accumulation of mutations in infecting the host and jumped into human beings. These findings indicate that if the epidemic expands, there may be a human-animal-human transmission route, which will increase the difficulty of disease prevention and control. Frontiers Media S.A. 2022-03-04 /pmc/articles/PMC8931700/ /pubmed/35308363 http://dx.doi.org/10.3389/fmicb.2022.781770 Text en Copyright © 2022 Sun, Wang, Wang, Wang, Tian, Yang and Liao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Sun, Hailiang Wang, Ailan Wang, Lixia Wang, Bing Tian, Geng Yang, Jialiang Liao, Ming Systematic Tracing of Susceptible Animals to SARS-CoV-2 by a Bioinformatics Framework |
title | Systematic Tracing of Susceptible Animals to SARS-CoV-2 by a Bioinformatics Framework |
title_full | Systematic Tracing of Susceptible Animals to SARS-CoV-2 by a Bioinformatics Framework |
title_fullStr | Systematic Tracing of Susceptible Animals to SARS-CoV-2 by a Bioinformatics Framework |
title_full_unstemmed | Systematic Tracing of Susceptible Animals to SARS-CoV-2 by a Bioinformatics Framework |
title_short | Systematic Tracing of Susceptible Animals to SARS-CoV-2 by a Bioinformatics Framework |
title_sort | systematic tracing of susceptible animals to sars-cov-2 by a bioinformatics framework |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931700/ https://www.ncbi.nlm.nih.gov/pubmed/35308363 http://dx.doi.org/10.3389/fmicb.2022.781770 |
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