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Dynamics of Retinal Vessel Loss After Acute Optic Neuritis in Patients With Relapsing Multiple Sclerosis

BACKGROUND AND OBJECTIVES: Rarefication of the retinal vasculature as measured by optical coherence tomography angiography (OCT-A) is a novel finding in patients with multiple sclerosis (MS). This study aimed to analyze longitudinal dynamics of the retinal vasculature following an acute inflammatory...

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Autores principales: Aly, Lilian, Noll, Christina, Wicklein, Rebecca, Wolf, Elisabeth, Romahn, Eva Feodora, Wauschkuhn, Josphine, Hosari, Sami, Mardin, Christian, Berthele, Achim, Hemmer, Bernhard, Korn, Thomas, Knier, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931743/
https://www.ncbi.nlm.nih.gov/pubmed/35301260
http://dx.doi.org/10.1212/NXI.0000000000001159
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author Aly, Lilian
Noll, Christina
Wicklein, Rebecca
Wolf, Elisabeth
Romahn, Eva Feodora
Wauschkuhn, Josphine
Hosari, Sami
Mardin, Christian
Berthele, Achim
Hemmer, Bernhard
Korn, Thomas
Knier, Benjamin
author_facet Aly, Lilian
Noll, Christina
Wicklein, Rebecca
Wolf, Elisabeth
Romahn, Eva Feodora
Wauschkuhn, Josphine
Hosari, Sami
Mardin, Christian
Berthele, Achim
Hemmer, Bernhard
Korn, Thomas
Knier, Benjamin
author_sort Aly, Lilian
collection PubMed
description BACKGROUND AND OBJECTIVES: Rarefication of the retinal vasculature as measured by optical coherence tomography angiography (OCT-A) is a novel finding in patients with multiple sclerosis (MS). This study aimed to analyze longitudinal dynamics of the retinal vasculature following an acute inflammatory relapse including acute optic neuritis (ON) and to search for associations with alterations of the retinal architecture and visual function. METHODS: This prospective longitudinal cohort study included patients with relapsing-remitting MS or clinically isolated syndrome having an acute ON (n = 20) or a non-ON relapse (n = 33). Patients underwent examinations at baseline and after 7, 14, 28, 90, and 180 days with OCT, OCT-A, and assessment of the high- (HCVA) and low-contrast visual acuity (LCVA). RESULTS: Retinal vessel loss of the superficial vascular complex (SVC) evolves early after ON and reaches a plateau between 90 and 180 days (relative vessel loss 15% ± 8% [mean ± SD]). In addition, an 18% ± 18% intraindividual increase of the foveal avascular zone (FAZ) is evident within 180 days after acute ON. Both SVC thinning and FAZ enlargement were associated with worse HCVA and LCVA. Rarefication of the SVC evolved simultaneously to thinning of the common ganglion cell and inner plexiform layer (GCIP) after ON. No alterations of the deep vascular complex were seen in eyes with ON, and no alterations of the retinal vasculature were recognized in patients having acute non-ON relapses. DISCUSSION: Rarefication of the SVC and growing of the FAZ evolve rapidly after ON and are linked to persistent visual disability. ON-related SVC thinning might be closely linked to GCIP atrophy and might occur due to an altered local metabolic activity within inner retinal layers.
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spelling pubmed-89317432022-03-21 Dynamics of Retinal Vessel Loss After Acute Optic Neuritis in Patients With Relapsing Multiple Sclerosis Aly, Lilian Noll, Christina Wicklein, Rebecca Wolf, Elisabeth Romahn, Eva Feodora Wauschkuhn, Josphine Hosari, Sami Mardin, Christian Berthele, Achim Hemmer, Bernhard Korn, Thomas Knier, Benjamin Neurol Neuroimmunol Neuroinflamm Research Article BACKGROUND AND OBJECTIVES: Rarefication of the retinal vasculature as measured by optical coherence tomography angiography (OCT-A) is a novel finding in patients with multiple sclerosis (MS). This study aimed to analyze longitudinal dynamics of the retinal vasculature following an acute inflammatory relapse including acute optic neuritis (ON) and to search for associations with alterations of the retinal architecture and visual function. METHODS: This prospective longitudinal cohort study included patients with relapsing-remitting MS or clinically isolated syndrome having an acute ON (n = 20) or a non-ON relapse (n = 33). Patients underwent examinations at baseline and after 7, 14, 28, 90, and 180 days with OCT, OCT-A, and assessment of the high- (HCVA) and low-contrast visual acuity (LCVA). RESULTS: Retinal vessel loss of the superficial vascular complex (SVC) evolves early after ON and reaches a plateau between 90 and 180 days (relative vessel loss 15% ± 8% [mean ± SD]). In addition, an 18% ± 18% intraindividual increase of the foveal avascular zone (FAZ) is evident within 180 days after acute ON. Both SVC thinning and FAZ enlargement were associated with worse HCVA and LCVA. Rarefication of the SVC evolved simultaneously to thinning of the common ganglion cell and inner plexiform layer (GCIP) after ON. No alterations of the deep vascular complex were seen in eyes with ON, and no alterations of the retinal vasculature were recognized in patients having acute non-ON relapses. DISCUSSION: Rarefication of the SVC and growing of the FAZ evolve rapidly after ON and are linked to persistent visual disability. ON-related SVC thinning might be closely linked to GCIP atrophy and might occur due to an altered local metabolic activity within inner retinal layers. Lippincott Williams & Wilkins 2022-03-17 /pmc/articles/PMC8931743/ /pubmed/35301260 http://dx.doi.org/10.1212/NXI.0000000000001159 Text en Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Research Article
Aly, Lilian
Noll, Christina
Wicklein, Rebecca
Wolf, Elisabeth
Romahn, Eva Feodora
Wauschkuhn, Josphine
Hosari, Sami
Mardin, Christian
Berthele, Achim
Hemmer, Bernhard
Korn, Thomas
Knier, Benjamin
Dynamics of Retinal Vessel Loss After Acute Optic Neuritis in Patients With Relapsing Multiple Sclerosis
title Dynamics of Retinal Vessel Loss After Acute Optic Neuritis in Patients With Relapsing Multiple Sclerosis
title_full Dynamics of Retinal Vessel Loss After Acute Optic Neuritis in Patients With Relapsing Multiple Sclerosis
title_fullStr Dynamics of Retinal Vessel Loss After Acute Optic Neuritis in Patients With Relapsing Multiple Sclerosis
title_full_unstemmed Dynamics of Retinal Vessel Loss After Acute Optic Neuritis in Patients With Relapsing Multiple Sclerosis
title_short Dynamics of Retinal Vessel Loss After Acute Optic Neuritis in Patients With Relapsing Multiple Sclerosis
title_sort dynamics of retinal vessel loss after acute optic neuritis in patients with relapsing multiple sclerosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931743/
https://www.ncbi.nlm.nih.gov/pubmed/35301260
http://dx.doi.org/10.1212/NXI.0000000000001159
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