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Self-reported symptoms and health complaints associated with exposure to Ixodes ricinus-borne pathogens
BACKGROUND: The impact of infections with tick-borne pathogens (TBPs) other than Borrelia burgdorferi (s.l.) and tick-borne encephalitis virus (TBEV) on public health in Europe remains unclear. Our goal is to evaluate whether the presence of these TBPs in ticks can be associated with self-reported h...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931963/ https://www.ncbi.nlm.nih.gov/pubmed/35303944 http://dx.doi.org/10.1186/s13071-022-05228-4 |
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author | Azagi, Tal Harms, Margriet Swart, Arno Fonville, Manoj Hoornstra, Dieuwertje Mughini-Gras, Lapo Hovius, Joppe W. Sprong, Hein van den Wijngaard, Cees |
author_facet | Azagi, Tal Harms, Margriet Swart, Arno Fonville, Manoj Hoornstra, Dieuwertje Mughini-Gras, Lapo Hovius, Joppe W. Sprong, Hein van den Wijngaard, Cees |
author_sort | Azagi, Tal |
collection | PubMed |
description | BACKGROUND: The impact of infections with tick-borne pathogens (TBPs) other than Borrelia burgdorferi (s.l.) and tick-borne encephalitis virus (TBEV) on public health in Europe remains unclear. Our goal is to evaluate whether the presence of these TBPs in ticks can be associated with self-reported health complaints. METHODS: We enrolled individuals who were bitten by I. ricinus between 2012 and 2015 and collected their relevant demographic and clinical information using a self-administered online questionnaire. A total of 4163 I. ricinus ticks sent by the participants were subject to molecular analyses for detection of specific TBPs. Associations between the presence of TBPs in ticks and self-reported complaints and symptoms were evaluated by means of a stepwise approach using a generalized linear model (GLM). RESULTS: Of 17 self-reported complaints and symptoms significant in the univariate analyses, 3 had a highly significant association (P < 0.01) with at least one TBP in the multivariate analysis. Self-reported Lyme borreliosis was significantly associated (P < 0.001) with B. burgdorferi (s.l.) infection. Facial paralysis was associated (P < 0.01) with infection with B. miyamotoi, N. mikurensis and R. helvetica. Finally, a significant association (P < 0.001) was found between nocturnal sweating and A. phagocytophilum. CONCLUSIONS: We found associations between the presence of TBPs in ticks feeding on humans and self-reported symptoms. Due to the subjective nature of such reports and the fact that infection was determined in the ticks and not in the patient samples, further prospective studies utilizing diagnostic modalities should be performed before any clinical outcome can be causally linked to infection with TBPs. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13071-022-05228-4. |
format | Online Article Text |
id | pubmed-8931963 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-89319632022-03-23 Self-reported symptoms and health complaints associated with exposure to Ixodes ricinus-borne pathogens Azagi, Tal Harms, Margriet Swart, Arno Fonville, Manoj Hoornstra, Dieuwertje Mughini-Gras, Lapo Hovius, Joppe W. Sprong, Hein van den Wijngaard, Cees Parasit Vectors Research BACKGROUND: The impact of infections with tick-borne pathogens (TBPs) other than Borrelia burgdorferi (s.l.) and tick-borne encephalitis virus (TBEV) on public health in Europe remains unclear. Our goal is to evaluate whether the presence of these TBPs in ticks can be associated with self-reported health complaints. METHODS: We enrolled individuals who were bitten by I. ricinus between 2012 and 2015 and collected their relevant demographic and clinical information using a self-administered online questionnaire. A total of 4163 I. ricinus ticks sent by the participants were subject to molecular analyses for detection of specific TBPs. Associations between the presence of TBPs in ticks and self-reported complaints and symptoms were evaluated by means of a stepwise approach using a generalized linear model (GLM). RESULTS: Of 17 self-reported complaints and symptoms significant in the univariate analyses, 3 had a highly significant association (P < 0.01) with at least one TBP in the multivariate analysis. Self-reported Lyme borreliosis was significantly associated (P < 0.001) with B. burgdorferi (s.l.) infection. Facial paralysis was associated (P < 0.01) with infection with B. miyamotoi, N. mikurensis and R. helvetica. Finally, a significant association (P < 0.001) was found between nocturnal sweating and A. phagocytophilum. CONCLUSIONS: We found associations between the presence of TBPs in ticks feeding on humans and self-reported symptoms. Due to the subjective nature of such reports and the fact that infection was determined in the ticks and not in the patient samples, further prospective studies utilizing diagnostic modalities should be performed before any clinical outcome can be causally linked to infection with TBPs. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13071-022-05228-4. BioMed Central 2022-03-18 /pmc/articles/PMC8931963/ /pubmed/35303944 http://dx.doi.org/10.1186/s13071-022-05228-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Azagi, Tal Harms, Margriet Swart, Arno Fonville, Manoj Hoornstra, Dieuwertje Mughini-Gras, Lapo Hovius, Joppe W. Sprong, Hein van den Wijngaard, Cees Self-reported symptoms and health complaints associated with exposure to Ixodes ricinus-borne pathogens |
title | Self-reported symptoms and health complaints associated with exposure to Ixodes ricinus-borne pathogens |
title_full | Self-reported symptoms and health complaints associated with exposure to Ixodes ricinus-borne pathogens |
title_fullStr | Self-reported symptoms and health complaints associated with exposure to Ixodes ricinus-borne pathogens |
title_full_unstemmed | Self-reported symptoms and health complaints associated with exposure to Ixodes ricinus-borne pathogens |
title_short | Self-reported symptoms and health complaints associated with exposure to Ixodes ricinus-borne pathogens |
title_sort | self-reported symptoms and health complaints associated with exposure to ixodes ricinus-borne pathogens |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931963/ https://www.ncbi.nlm.nih.gov/pubmed/35303944 http://dx.doi.org/10.1186/s13071-022-05228-4 |
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