Interleukin-10 genetically modified clinical-grade mesenchymal stromal cells markedly reinforced functional recovery after spinal cord injury via directing alternative activation of macrophages

BACKGROUND: After spinal cord injury (SCI), dysregulated or nonresolving inflammatory processes can severely disturb neuronal homeostasis and drive neurodegeneration. Although mesenchymal stromal cell (MSC)-based therapies have showed certain therapeutic efficacy, no MSC therapy has reached its full...

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Detalles Bibliográficos
Autores principales: Gao, Tianyun, Huang, Feifei, Wang, Wenqing, Xie, Yuanyuan, Wang, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931978/
https://www.ncbi.nlm.nih.gov/pubmed/35300585
http://dx.doi.org/10.1186/s11658-022-00325-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931978/
https://www.ncbi.nlm.nih.gov/pubmed/35300585
http://dx.doi.org/10.1186/s11658-022-00325-9

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