Cargando…

Interleukin-10 genetically modified clinical-grade mesenchymal stromal cells markedly reinforced functional recovery after spinal cord injury via directing alternative activation of macrophages

BACKGROUND: After spinal cord injury (SCI), dysregulated or nonresolving inflammatory processes can severely disturb neuronal homeostasis and drive neurodegeneration. Although mesenchymal stromal cell (MSC)-based therapies have showed certain therapeutic efficacy, no MSC therapy has reached its full...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gao, Tianyun, Huang, Feifei, Wang, Wenqing, Xie, Yuanyuan, Wang, Bin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931978/ https://www.ncbi.nlm.nih.gov/pubmed/35300585 http://dx.doi.org/10.1186/s11658-022-00325-9

Ejemplares similares

Engineered basic fibroblast growth factor-overexpressing human umbilical cord-derived mesenchymal stem cells improve the proliferation and neuronal differentiation of endogenous neural stem cells and functional recovery of spinal cord injury by activating the PI3K-Akt-GSK-3β signaling pathway
por: Huang, Feifei, et al.
Publicado: (2021)

Engineered clinical-grade mesenchymal stromal cells combating SARS-CoV-2 omicron variants by secreting effective neutralizing antibodies
por: Wang, Yanning, et al.
Publicado: (2023)

Interleukin-1 participates in the classical and alternative activation of microglia/macrophages after spinal cord injury
por: Sato, Atsushi, et al.
Publicado: (2012)

Azithromycin drives alternative macrophage activation and improves recovery and tissue sparing in contusion spinal cord injury
por: Zhang, Bei, et al.
Publicado: (2015)

A long-term anti-inflammation markedly alleviated high-fat diet-induced obesity by repeated administrations of overexpressing IL10 human umbilical cord-derived mesenchymal stromal cells
por: Wang, Liudi, et al.
Publicado: (2022)

Interleukin-25 is detrimental for recovery after spinal cord injury in mice
por: Dooley, Dearbhaile, et al.
Publicado: (2016)

HDAC3 Inhibition Promotes Alternative Activation of Macrophages but Does Not Affect Functional Recovery after Spinal Cord Injury
por: Sanchez, Selien, et al.
Publicado: (2018)

Blockade of interleukin-6 signaling inhibits the classic pathway and promotes an alternative pathway of macrophage activation after spinal cord injury in mice
por: Guerrero, Alexander Rodriguez, et al.
Publicado: (2012)

Cell-Based Delivery of Interleukin-13 Directs Alternative Activation of Macrophages Resulting in Improved Functional Outcome after Spinal Cord Injury
por: Dooley, Dearbhaile, et al.
Publicado: (2016)

Low-level laser facilitates alternatively activated macrophage/microglia polarization and promotes functional recovery after crush spinal cord injury in rats
por: Song, Ji Wei, et al.
Publicado: (2017)

Targeted transplantation of engineered mitochondrial compound promotes functional recovery after spinal cord injury by enhancing macrophage phagocytosis
por: Xu, Jiaqi, et al.
Publicado: (2023)

Canine Bone Marrow Stromal Cells Promote Functional Recovery in Mice with Spinal Cord Injury
por: ODA, Yasutaka, et al.
Publicado: (2014)

Neuroprotective effects of interleukin 10 in spinal cord injury
por: Li, Juan, et al.
Publicado: (2023)

Interleukin-4 Ameliorates the Functional Recovery of Intracerebral Hemorrhage Through the Alternative Activation of Microglia/Macrophage
por: Yang, Jianjing, et al.
Publicado: (2016)

Macrophage-based delivery of interleukin-13 improves functional and histopathological outcomes following spinal cord injury
por: Van Broeckhoven, Jana, et al.
Publicado: (2022)

Interleukin-4 and interleukin-13 induce different metabolic profiles in microglia and macrophages that relate with divergent outcomes after spinal cord injury
por: Amo-Aparicio, Jesus, et al.
Publicado: (2021)

Snx27 Deletion Promotes Recovery From Spinal Cord Injury by Neuroprotection and Reduces Macrophage/Microglia Proliferation
por: Zeng, Yuzhe, et al.
Publicado: (2018)

Interleukin-17A regulates ependymal cell proliferation and functional recovery after spinal cord injury in mice
por: Miyajima, Hisao, et al.
Publicado: (2021)

Transneuronal delivery of hyper-interleukin-6 enables functional recovery after severe spinal cord injury in mice
por: Leibinger, Marco, et al.
Publicado: (2021)

Endocrine Therapy for the Functional Recovery of Spinal Cord Injury
por: Wang, Hui, et al.
Publicado: (2020)

Predictors of interleukin-33 and thymic stromal lymphopoietin levels in cord blood
por: Ashley-Martin, Jillian, et al.
Publicado: (2015)

Transcutaneous Electrical Spinal Cord Stimulation to Promote Recovery in Chronic Spinal Cord Injury
por: Tefertiller, Candace, et al.
Publicado: (2022)

Lithium promotes recovery after spinal cord injury
por: Zhao, Ying-Jie, et al.
Publicado: (2021)

Biomaterials reinforced MSCs transplantation for spinal cord injury repair
por: Ma, Teng, et al.
Publicado: (2022)

Mesenchymal Stromal Cell Therapy in Spinal Cord Injury: Mechanisms and Prospects
por: Xie, Ji-Le, et al.
Publicado: (2022)

Surgical Outcomes of High-Grade Spinal Cord Gliomas
por: Seki, Toshitaka, et al.
Publicado: (2015)

Maladaptive spinal plasticity opposes spinal learning and recovery in spinal cord injury
por: Ferguson, Adam R., et al.
Publicado: (2012)

Polypyrrole/polylactic acid nanofibrous scaffold cotransplanted with bone marrow stromal cells promotes the functional recovery of spinal cord injury in rats
por: , Raynald, et al.
Publicado: (2019)

Epothilone B impairs functional recovery after spinal cord injury by increasing secretion of macrophage colony-stimulating factor
por: Mao, Liang, et al.
Publicado: (2017)

Inhibition of UTX/KDM6A improves recovery of spinal cord injury by attenuating BSCB permeability and macrophage infiltration through the MLCK/p-MLC pathway
por: Xie, Yong, et al.
Publicado: (2023)

Spinal Cord Injury Causes Marked Tissue Rearrangement in the Urethra—Experimental Study in the Rat
por: Ferreira, Ana, et al.
Publicado: (2022)

A Biomimetic Nonwoven-Reinforced Hydrogel for Spinal Cord Injury Repair
por: Golland, Ben, et al.
Publicado: (2022)

Gut dysbiosis impairs recovery after spinal cord injury
por: Kigerl, Kristina A., et al.
Publicado: (2016)

Treadmill exercise with bone marrow stromal cells transplantation potentiates recovery of locomotor function after spinal cord injury in rats
por: Kim, You-Mi, et al.
Publicado: (2017)

Three-dimensional bioprinting sodium alginate/gelatin scaffold combined with neural stem cells and oligodendrocytes markedly promoting nerve regeneration after spinal cord injury
por: Liu, Shuo, et al.
Publicado: (2022)

Implantation with SHED sheet induced with homogenate protein of spinal cord promotes functional recovery from spinal cord injury in rats
por: Mi, Sisi, et al.
Publicado: (2023)

Surgical Considerations to Improve Recovery in Acute Spinal Cord Injury
por: Tabarestani, Troy Q., et al.
Publicado: (2022)

Case of Inflammation of the Anterior Columns of the Spinal Cord. Recovery
por: Crockatt, Wm.
Publicado: (1867)

Nimodipine Promotes Functional Recovery After Spinal Cord Injury in Rats
por: Guo, Fangliang, et al.
Publicado: (2021)

Low-Grade Inflammation and Spinal Cord Injury: Exercise as Therapy?
por: da Silva Alves, Eduardo, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_bu4eno4k5g7rcv1cdkduk4fh2l