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Association of serum methionine metabolites with non-alcoholic fatty liver disease: a cross-sectional study
BACKGROUND AND PROJECT: Non-alcoholic fatty liver disease (NAFLD) is viewed as the hepatic manifestation of metabolic syndrome. Methionine metabolites have been linked to metabolic syndrome and its related diseases. Whether serum methionine metabolites levels are associated with NAFLD remains unclea...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8932073/ https://www.ncbi.nlm.nih.gov/pubmed/35303918 http://dx.doi.org/10.1186/s12986-022-00647-7 |
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author | Tang, Yi Chen, Xu Chen, Qian Xiao, Jinghe Mi, Jiaxin Liu, Qiannan You, Yiran Chen, Yuming Ling, Wenhua |
author_facet | Tang, Yi Chen, Xu Chen, Qian Xiao, Jinghe Mi, Jiaxin Liu, Qiannan You, Yiran Chen, Yuming Ling, Wenhua |
author_sort | Tang, Yi |
collection | PubMed |
description | BACKGROUND AND PROJECT: Non-alcoholic fatty liver disease (NAFLD) is viewed as the hepatic manifestation of metabolic syndrome. Methionine metabolites have been linked to metabolic syndrome and its related diseases. Whether serum methionine metabolites levels are associated with NAFLD remains unclear. The study aimed to assess the association between methionine metabolites and NAFLD. METHODS: This cross-sectional study included a total of 2814 individuals aged 40–75 years old. All participants underwent anthropometric measurements, laboratory tests, dietary assessment and abdominal ultrasonography. Multivariable logistic regression analysis was performed to estimate the association of methionine metabolites with NAFLD. RESULTS: Overall, 1446 with and 1368 without NAFLD were enrolled in this study. Participants with NAFLD had significantly higher serum S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH) and homocysteine (Hcy) levels, and a lower S-adenosylmethionine/S-adenosylhomocysteine (SAM/SAH) ratio than those without NAFLD (all P < 0.001). After adjusting multiple confounders, odds ratios (95% confidence interval) for quartile 4 versus quartile 1 of SAH, Hcy and SAM/SAH ratio were 1.65 (1.27–2.14), 1.63 (1.26–2.12) and 0.63 (0.49–0.83), respectively (all P for trend < 0.01). In addition, serum SAH, Hcy levels and SAM/SAH ratio were significantly correlated with the degree of hepatic steatosis (all P for trend < 0.001). CONCLUSION: Elevated serum SAH, Hcy levels and lower SAM/SAH ratio may be independently associated with the presence of NAFLD in middle-aged and elder Chinese. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12986-022-00647-7. |
format | Online Article Text |
id | pubmed-8932073 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-89320732022-03-23 Association of serum methionine metabolites with non-alcoholic fatty liver disease: a cross-sectional study Tang, Yi Chen, Xu Chen, Qian Xiao, Jinghe Mi, Jiaxin Liu, Qiannan You, Yiran Chen, Yuming Ling, Wenhua Nutr Metab (Lond) Research BACKGROUND AND PROJECT: Non-alcoholic fatty liver disease (NAFLD) is viewed as the hepatic manifestation of metabolic syndrome. Methionine metabolites have been linked to metabolic syndrome and its related diseases. Whether serum methionine metabolites levels are associated with NAFLD remains unclear. The study aimed to assess the association between methionine metabolites and NAFLD. METHODS: This cross-sectional study included a total of 2814 individuals aged 40–75 years old. All participants underwent anthropometric measurements, laboratory tests, dietary assessment and abdominal ultrasonography. Multivariable logistic regression analysis was performed to estimate the association of methionine metabolites with NAFLD. RESULTS: Overall, 1446 with and 1368 without NAFLD were enrolled in this study. Participants with NAFLD had significantly higher serum S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH) and homocysteine (Hcy) levels, and a lower S-adenosylmethionine/S-adenosylhomocysteine (SAM/SAH) ratio than those without NAFLD (all P < 0.001). After adjusting multiple confounders, odds ratios (95% confidence interval) for quartile 4 versus quartile 1 of SAH, Hcy and SAM/SAH ratio were 1.65 (1.27–2.14), 1.63 (1.26–2.12) and 0.63 (0.49–0.83), respectively (all P for trend < 0.01). In addition, serum SAH, Hcy levels and SAM/SAH ratio were significantly correlated with the degree of hepatic steatosis (all P for trend < 0.001). CONCLUSION: Elevated serum SAH, Hcy levels and lower SAM/SAH ratio may be independently associated with the presence of NAFLD in middle-aged and elder Chinese. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12986-022-00647-7. BioMed Central 2022-03-18 /pmc/articles/PMC8932073/ /pubmed/35303918 http://dx.doi.org/10.1186/s12986-022-00647-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Tang, Yi Chen, Xu Chen, Qian Xiao, Jinghe Mi, Jiaxin Liu, Qiannan You, Yiran Chen, Yuming Ling, Wenhua Association of serum methionine metabolites with non-alcoholic fatty liver disease: a cross-sectional study |
title | Association of serum methionine metabolites with non-alcoholic fatty liver disease: a cross-sectional study |
title_full | Association of serum methionine metabolites with non-alcoholic fatty liver disease: a cross-sectional study |
title_fullStr | Association of serum methionine metabolites with non-alcoholic fatty liver disease: a cross-sectional study |
title_full_unstemmed | Association of serum methionine metabolites with non-alcoholic fatty liver disease: a cross-sectional study |
title_short | Association of serum methionine metabolites with non-alcoholic fatty liver disease: a cross-sectional study |
title_sort | association of serum methionine metabolites with non-alcoholic fatty liver disease: a cross-sectional study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8932073/ https://www.ncbi.nlm.nih.gov/pubmed/35303918 http://dx.doi.org/10.1186/s12986-022-00647-7 |
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