Cargando…

Fruitflow inhibits platelet function by suppressing Akt/GSK3β, Syk/PLCγ2 and p38 MAPK phosphorylation in collagen-stimulated platelets

BACKGROUND: Platelets play an important role in the progression of atherosclerosis and cardiovascular events. The inhibition of platelet function is a main strategy to reduce risk of cardiovascular events. Some studies have shown that tomato extracts inhibit platelet function, but the molecular mech...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Huilian, Zhang, Shenghao, Wang, Hui, Bao, Li, Wu, Wei, Qi, Ruomei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8932123/ https://www.ncbi.nlm.nih.gov/pubmed/35300669 http://dx.doi.org/10.1186/s12906-022-03558-5

Ejemplares similares

Water-Soluble Tomato Extract Fruitflow Alters the Phosphoproteomic Profile of Collagen-Stimulated Platelets
por: Zhang, Shenghao, et al.
Publicado: (2021)

Resveratrol Confers Vascular Protection by Suppressing TLR4/Syk/NLRP3 Signaling in Oxidized Low-Density Lipoprotein-Activated Platelets
por: Xue, Yun, et al.
Publicado: (2021)

Platelet hyperactivity in COVID-19: Can the tomato extract Fruitflow® be used as an antiplatelet regime?
por: O'Kennedy, Niamh, et al.
Publicado: (2021)

Licochalcone A Prevents Platelet Activation and Thrombus Formation through the Inhibition of PLCγ2-PKC, Akt, and MAPK Pathways
por: Lien, Li-Ming, et al.
Publicado: (2017)

Astilbe chinensis Modulates Platelet Function via Impaired MAPK and PLCγ2 Expression
por: Jeon, Bo-Ra, et al.
Publicado: (2018)

Amarogentin, a Secoiridoid Glycoside, Abrogates Platelet Activation through PLCγ2-PKC and MAPK Pathways
por: Yen, Ting-Lin, et al.
Publicado: (2014)

Phosphorylation on Syk Y342 is important for both ITAM and hemITAM signaling in platelets
por: Kostyak, John C., et al.
Publicado: (2022)

Rac Inhibition Causes Impaired GPVI Signalling in Human Platelets through GPVI Shedding and Reduction in PLCγ2 Phosphorylation
por: Neagoe, Raluca A. I., et al.
Publicado: (2022)

Esculetin, a Coumarin Derivative, Prevents Thrombosis: Inhibitory Signaling on PLCγ2–PKC–AKT Activation in Human Platelets
por: Hsia, Chih-Wei, et al.
Publicado: (2019)

Role of Platelet Glycoprotein VI and Tyrosine Kinase Syk in Thrombus Formation on Collagen-Like Surfaces
por: Jooss, Natalie J., et al.
Publicado: (2019)

Integrin α(2)β(1) mediates outside-in regulation of platelet spreading on collagen through activation of Src kinases and PLCγ2
por: Inoue, Osamu, et al.
Publicado: (2003)

Opposing Roles of GSK3α and GSK3β Phosphorylation in Platelet Function and Thrombosis
por: Moore, Samantha F., et al.
Publicado: (2021)

Pistacia chinensis Methanolic Extract Attenuated MAPK and Akt Phosphorylations in ADP Stimulated Rat Platelets In Vitro
por: Park, Ji Young, et al.
Publicado: (2012)

Evaluation of the equivalence of different intakes of Fruitflow in affecting platelet aggregation and thrombin generation capacity in a randomized, double-blinded pilot study in male subjects
por: Das, Ranjit K., et al.
Publicado: (2021)

Gallic Acid Attenuates Platelet Activation and Platelet-Leukocyte Aggregation: Involving Pathways of Akt and GSK3β
por: Chang, Shih-Sheng, et al.
Publicado: (2012)

Feedback Regulation of Syk by Protein Kinase C in Human Platelets
por: Makhoul, Stephanie, et al.
Publicado: (2019)

Platelet Adhesion to Podoplanin Under Flow is Mediated by the Receptor CLEC-2 and Stabilised by Src/Syk-Dependent Platelet Signalling
por: Navarro-Núñez, Leyre, et al.
Publicado: (2015)

Structural basis for the activation of PLC-γ isozymes by phosphorylation and cancer-associated mutations
por: Hajicek, Nicole, et al.
Publicado: (2019)

Syk Activity Is Dispensable for Platelet GP1b-IX-V Signaling
por: Badolia, Rachit, et al.
Publicado: (2017)

Unconjugated Bilirubin exerts Pro-Apoptotic Effect on Platelets via p38-MAPK activation
por: NaveenKumar, Somanathapura K., et al.
Publicado: (2015)

Dual role of the p38 MAPK/cPLA(2) pathway in the regulation of platelet apoptosis induced by ABT-737 and strong platelet agonists
por: Rukoyatkina, N, et al.
Publicado: (2013)

Salidroside inhibits platelet function and thrombus formation through AKT/GSK3β signaling pathway
por: Wei, Guangyu, et al.
Publicado: (2020)

Platelet Mechanosensing of Collagen Matrices
por: Kee, Matthew F., et al.
Publicado: (2015)

Fruitflow(®): the first European Food Safety Authority-approved natural cardio-protective functional ingredient
por: O’Kennedy, Niamh, et al.
Publicado: (2016)

Dietary Antiplatelets: A New Perspective on the Health Benefits of the Water-Soluble Tomato Concentrate Fruitflow(®)
por: O’Kennedy, Niamh, et al.
Publicado: (2021)

The microtubule-associated protein tau is phosphorylated by Syk
por: Lebouvier, Thibaud, et al.
Publicado: (2008)

Endogenous BDNF augments NMDA receptor phosphorylation in the spinal cord via PLCγ, PKC, and PI3K/Akt pathways during colitis
por: Liu, Miao, et al.
Publicado: (2015)

The inhibition of PLCγ1 protects chondrocytes against osteoarthritis, implicating its binding to Akt
por: Cai, Heguo, et al.
Publicado: (2017)

New Insights into the p38γ and p38δ MAPK Pathways
por: Risco, Ana, et al.
Publicado: (2012)

Interleukin-6 stimulates Akt and p38 MAPK phosphorylation and fibroblast migration in non-diabetic but not diabetic mice
por: Nishikai-Yan Shen, Tsubame, et al.
Publicado: (2017)

Plantamajoside modulates the proliferation, stemness, and apoptosis of lung carcinoma via restraining p38MAPK and AKT phosphorylation
por: Li, Yazhou, et al.
Publicado: (2020)

Postnatal Syk deletion in mice clarifies the function of Syk in an anti-collagen antibody-induced arthritis model
por: Ozaki, Naoko, et al.
Publicado: (2012)

FGFR1-Induced Epithelial to Mesenchymal Transition through MAPK/PLCγ/COX-2-Mediated Mechanisms
por: Tomlinson, Darren C., et al.
Publicado: (2012)

Anti-Osteoclastogenic Activity of Praeruptorin A via Inhibition of p38/Akt-c-Fos-NFATc1 Signaling and PLCγ-Independent Ca(2+) Oscillation
por: Yeon, Jeong-Tae, et al.
Publicado: (2014)

Butein sensitizes HeLa cells to cisplatin through the AKT and ERK/p38 MAPK pathways by targeting FoxO3a
por: ZHANG, LIRUI, et al.
Publicado: (2015)

Central role of PI3K–SYK interaction in fibrinogen‐induced lamellipodia and filopodia formation in platelets
por: Singh, Raghvendra
Publicado: (2016)

p38γ and p38δ Mitogen Activated Protein Kinases (MAPKs), New Stars in the MAPK Galaxy
por: Escós, Alejandra, et al.
Publicado: (2016)

p38 MAPK- and Akt-mediated p300 phosphorylation regulates its degradation to facilitate nucleotide excision repair
por: Wang, Qi-En, et al.
Publicado: (2013)

Syk phosphorylation – a gravisensitive step in macrophage signalling
por: Brungs, Sonja, et al.
Publicado: (2015)

Recycling of platelet phosphorylation and cytoskeletal assembly
Publicado: (1984)

Cannot write session to /tmp/vufind_sessions/sess_06d1eolu394deqpg18anuncq3u