Protective effect of Sophora pachycarpa seed extract on carbon tetrachloride-induced toxicity in rats

The aim of the present study was to investigate the protective effect of the Sophora pachycarpa (S. pachycarpa) seed extract against carbon tetrachloride-induced toxicity on body organs, blood, and biochemical factors. In this investigation, 40 male Wistar rats weighing 200–250 g were randomly divided into 5 groups: group I was used as control, group II received carbon tetrachloride (CCl(4)) (IP, 1 mL/kg) on day 21, group III and group IV received S. pachycarpa seed extract at doses of 150 mg/kg and 300 mg/kg, respectively for 21 days by oral gavage and CCl(4) on day 21, group V received silymarin (300 mg/kg) for 21 days by oral gavage and CCl(4) on day 21. CCl(4) showed an increase of serum renal and hepatic markers creatinine, urea, blood urea nitrogen (BUN), and uric acid, alkaline phosphatase (ALP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT). Also, it significantly increased MDA level, and decreased CAT, FRAP, GSH, and SOD in the liver and kidney tissues. These changes and also hematological and histopathological alterations were significantly ameliorated by S. pachycarpa seed extract before CCl(4) administration. In conclusion, the data obtained in our investigation confirm the protective effect of S. pachycarpa against acute exposure to CCl(4)-induced organ toxicity in rats. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12906-022-03554-9.