TGFβ receptor inhibition unleashes interferon-β production by tumor-associated macrophages and enhances radiotherapy efficacy

BACKGROUND: Transforming growth factor-beta (TGFβ) can limit the efficacy of cancer treatments, including radiotherapy (RT), by inducing an immunosuppressive tumor environment. The association of TGFβ with impaired T cell infiltration and antitumor immunity is known, but the mechanisms by which TGFβ...

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Detalles Bibliográficos
Autores principales: Hamon, Pauline, Gerbé De Thoré, Marine, Classe, Marion, Signolle, Nicolas, Liu, Winchygn, Bawa, Olivia, Meziani, Lydia, Clémenson, Céline, Milliat, Fabien, Deutsch, Eric, Mondini, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8932273/
https://www.ncbi.nlm.nih.gov/pubmed/35301235
http://dx.doi.org/10.1136/jitc-2021-003519

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8932273/
https://www.ncbi.nlm.nih.gov/pubmed/35301235
http://dx.doi.org/10.1136/jitc-2021-003519

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