Closing the gap: Tricellulin/α-catenin interaction maintains epithelial integrity at vertices

Tricellular junctions play a critical role in regulating epithelial barrier function. In this issue, Cho et al. (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202009037) demonstrate a novel interaction between tricellulin and α-catenin, which connects tricellular junctions to the actomyosin cytosk...

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Detalles Bibliográficos
Autores principales: van den Goor, Lotte, Miller, Ann L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8932530/
https://www.ncbi.nlm.nih.gov/pubmed/35191951
http://dx.doi.org/10.1083/jcb.202202009
Descripción
Sumario:Tricellular junctions play a critical role in regulating epithelial barrier function. In this issue, Cho et al. (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202009037) demonstrate a novel interaction between tricellulin and α-catenin, which connects tricellular junctions to the actomyosin cytoskeleton, thus supporting the epithelial barrier at cell vertices.

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