Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function

Obesity is one of the leading preventable causes of cancer; however, little is known about the effects of obesity on anti-tumor immunity. Here, we investigated the effects of obesity on CD8 T cells in mouse models and patients with endometrial cancer. Our findings revealed that CD8 T cell infiltrati...

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Detalles Bibliográficos
Autores principales: Dyck, Lydia, Prendeville, Hannah, Raverdeau, Mathilde, Wilk, Mieszko M., Loftus, Roisin M., Douglas, Aaron, McCormack, Janet, Moran, Bruce, Wilkinson, Michael, Mills, Evanna L., Doughty, Michael, Fabre, Aurelie, Heneghan, Helen, LeRoux, Carel, Hogan, Andrew, Chouchani, Edward T., O’Shea, Donal, Brennan, Donal, Lynch, Lydia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8932531/
https://www.ncbi.nlm.nih.gov/pubmed/35103755
http://dx.doi.org/10.1084/jem.20210042

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