Epitope convergence of broadly HIV-1 neutralizing IgA and IgG antibody lineages in a viremic controller

Decrypting the B cell ontogeny of HIV-1 broadly neutralizing antibodies (bNAbs) is paramount for vaccine design. Here, we characterized IgA and IgG bNAbs of three distinct B cell lineages in a viremic controller, two of which comprised only IgG(+) or IgA(+) blood memory B cells; the third combined b...

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Detalles Bibliográficos
Autores principales: Lorin, Valérie, Fernández, Ignacio, Masse-Ranson, Guillemette, Bouvin-Pley, Mélanie, Molinos-Albert, Luis M., Planchais, Cyril, Hieu, Thierry, Péhau-Arnaudet, Gérard, Hrebík, Dominik, Girelli-Zubani, Giulia, Fiquet, Oriane, Guivel-Benhassine, Florence, Sanders, Rogier W., Walker, Bruce D., Schwartz, Olivier, Scheid, Johannes F., Dimitrov, Jordan D., Plevka, Pavel, Braibant, Martine, Seaman, Michael S., Bontems, François, Di Santo, James P., Rey, Félix A., Mouquet, Hugo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8932546/
https://www.ncbi.nlm.nih.gov/pubmed/35230385
http://dx.doi.org/10.1084/jem.20212045

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