Cargando…

The effects of exercise training on autonomic and hemodynamic responses to muscle metaboreflex in people living with HIV/AIDS: A randomized clinical trial protocol

BACKGROUND: People living with HIV (PLHIV) present impaired muscle metaboreflex, which may lead to exercise intolerance and increased cardiovascular risk. The muscle metaboreflex adaptations to exercise training in these patients are unknown. The present study aims to investigate the effects of a su...

Descripción completa

Detalles Bibliográficos
Autores principales: Gama, Gabriel, dos Santos Rangel, Marcus Vinicius, de Oliveira Coelho, Vanessa Cunha, Paz, Gabriela Andrade, de Matos, Catarina Vieira Branco, Silva, Bárbara Pinheiro, Lopes, Gabriella de Oliveira, Lopes, Karynne Grutter, Farinatti, Paulo, Borges, Juliana Pereira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8932586/
https://www.ncbi.nlm.nih.gov/pubmed/35303017
http://dx.doi.org/10.1371/journal.pone.0265516
_version_ 1784671472612016128
author Gama, Gabriel
dos Santos Rangel, Marcus Vinicius
de Oliveira Coelho, Vanessa Cunha
Paz, Gabriela Andrade
de Matos, Catarina Vieira Branco
Silva, Bárbara Pinheiro
Lopes, Gabriella de Oliveira
Lopes, Karynne Grutter
Farinatti, Paulo
Borges, Juliana Pereira
author_facet Gama, Gabriel
dos Santos Rangel, Marcus Vinicius
de Oliveira Coelho, Vanessa Cunha
Paz, Gabriela Andrade
de Matos, Catarina Vieira Branco
Silva, Bárbara Pinheiro
Lopes, Gabriella de Oliveira
Lopes, Karynne Grutter
Farinatti, Paulo
Borges, Juliana Pereira
author_sort Gama, Gabriel
collection PubMed
description BACKGROUND: People living with HIV (PLHIV) present impaired muscle metaboreflex, which may lead to exercise intolerance and increased cardiovascular risk. The muscle metaboreflex adaptations to exercise training in these patients are unknown. The present study aims to investigate the effects of a supervised multimodal exercise training on hemodynamic and autonomic responses to muscle metaboreflex activation in PLHIV. METHODS AND DESIGN: In this randomized clinical trial protocol, 42 PLHIV aged 30–50 years will be randomly assigned at a ratio of 1:1 into an intervention or a control group. The intervention group will perform exercise training (3x/week during 12 weeks) and the control group will remain physically inactive. A reference group composed of 21 HIV-uninfected individuals will be included. Primary outcomes will be blood pressure and heart rate variability indices assessed during resting, mental stress, and activation of muscle metaboreflex by a digital sphygmomanometer and a heart rate monitor; respectively. Mental stress will be induced by the Stroop Color-Word test and muscle metaboreflex will be activated through a post-exercise circulatory arrest (PECA) protocol, being the latter performed without and with the application of a capsaicin-based analgesic balm in the exercised limb. Secondary outcomes will be heart rate, peripheral vascular resistance, stroke volume, cardiac output, blood lactate, anthropometric markers and handgrip maximal voluntary contraction. The intervention and control groups of PLHIV will be evaluated at baseline and after the intervention, while the HIV-uninfected reference group only at baseline. DISCUSSION: The findings of the present study may help to elucidate the muscle metaboreflex adaptations to exercise training in PLHIV. TRIAL REGISTRATION: This study will be performed at University of Rio de Janeiro State following registration at ClinicalTrials.gov as NCT04512456 on August 13, 2020.
format Online
Article
Text
id pubmed-8932586
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-89325862022-03-19 The effects of exercise training on autonomic and hemodynamic responses to muscle metaboreflex in people living with HIV/AIDS: A randomized clinical trial protocol Gama, Gabriel dos Santos Rangel, Marcus Vinicius de Oliveira Coelho, Vanessa Cunha Paz, Gabriela Andrade de Matos, Catarina Vieira Branco Silva, Bárbara Pinheiro Lopes, Gabriella de Oliveira Lopes, Karynne Grutter Farinatti, Paulo Borges, Juliana Pereira PLoS One Study Protocol BACKGROUND: People living with HIV (PLHIV) present impaired muscle metaboreflex, which may lead to exercise intolerance and increased cardiovascular risk. The muscle metaboreflex adaptations to exercise training in these patients are unknown. The present study aims to investigate the effects of a supervised multimodal exercise training on hemodynamic and autonomic responses to muscle metaboreflex activation in PLHIV. METHODS AND DESIGN: In this randomized clinical trial protocol, 42 PLHIV aged 30–50 years will be randomly assigned at a ratio of 1:1 into an intervention or a control group. The intervention group will perform exercise training (3x/week during 12 weeks) and the control group will remain physically inactive. A reference group composed of 21 HIV-uninfected individuals will be included. Primary outcomes will be blood pressure and heart rate variability indices assessed during resting, mental stress, and activation of muscle metaboreflex by a digital sphygmomanometer and a heart rate monitor; respectively. Mental stress will be induced by the Stroop Color-Word test and muscle metaboreflex will be activated through a post-exercise circulatory arrest (PECA) protocol, being the latter performed without and with the application of a capsaicin-based analgesic balm in the exercised limb. Secondary outcomes will be heart rate, peripheral vascular resistance, stroke volume, cardiac output, blood lactate, anthropometric markers and handgrip maximal voluntary contraction. The intervention and control groups of PLHIV will be evaluated at baseline and after the intervention, while the HIV-uninfected reference group only at baseline. DISCUSSION: The findings of the present study may help to elucidate the muscle metaboreflex adaptations to exercise training in PLHIV. TRIAL REGISTRATION: This study will be performed at University of Rio de Janeiro State following registration at ClinicalTrials.gov as NCT04512456 on August 13, 2020. Public Library of Science 2022-03-18 /pmc/articles/PMC8932586/ /pubmed/35303017 http://dx.doi.org/10.1371/journal.pone.0265516 Text en © 2022 Gama et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Study Protocol
Gama, Gabriel
dos Santos Rangel, Marcus Vinicius
de Oliveira Coelho, Vanessa Cunha
Paz, Gabriela Andrade
de Matos, Catarina Vieira Branco
Silva, Bárbara Pinheiro
Lopes, Gabriella de Oliveira
Lopes, Karynne Grutter
Farinatti, Paulo
Borges, Juliana Pereira
The effects of exercise training on autonomic and hemodynamic responses to muscle metaboreflex in people living with HIV/AIDS: A randomized clinical trial protocol
title The effects of exercise training on autonomic and hemodynamic responses to muscle metaboreflex in people living with HIV/AIDS: A randomized clinical trial protocol
title_full The effects of exercise training on autonomic and hemodynamic responses to muscle metaboreflex in people living with HIV/AIDS: A randomized clinical trial protocol
title_fullStr The effects of exercise training on autonomic and hemodynamic responses to muscle metaboreflex in people living with HIV/AIDS: A randomized clinical trial protocol
title_full_unstemmed The effects of exercise training on autonomic and hemodynamic responses to muscle metaboreflex in people living with HIV/AIDS: A randomized clinical trial protocol
title_short The effects of exercise training on autonomic and hemodynamic responses to muscle metaboreflex in people living with HIV/AIDS: A randomized clinical trial protocol
title_sort effects of exercise training on autonomic and hemodynamic responses to muscle metaboreflex in people living with hiv/aids: a randomized clinical trial protocol
topic Study Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8932586/
https://www.ncbi.nlm.nih.gov/pubmed/35303017
http://dx.doi.org/10.1371/journal.pone.0265516
work_keys_str_mv AT gamagabriel theeffectsofexercisetrainingonautonomicandhemodynamicresponsestomusclemetaboreflexinpeoplelivingwithhivaidsarandomizedclinicaltrialprotocol
AT dossantosrangelmarcusvinicius theeffectsofexercisetrainingonautonomicandhemodynamicresponsestomusclemetaboreflexinpeoplelivingwithhivaidsarandomizedclinicaltrialprotocol
AT deoliveiracoelhovanessacunha theeffectsofexercisetrainingonautonomicandhemodynamicresponsestomusclemetaboreflexinpeoplelivingwithhivaidsarandomizedclinicaltrialprotocol
AT pazgabrielaandrade theeffectsofexercisetrainingonautonomicandhemodynamicresponsestomusclemetaboreflexinpeoplelivingwithhivaidsarandomizedclinicaltrialprotocol
AT dematoscatarinavieirabranco theeffectsofexercisetrainingonautonomicandhemodynamicresponsestomusclemetaboreflexinpeoplelivingwithhivaidsarandomizedclinicaltrialprotocol
AT silvabarbarapinheiro theeffectsofexercisetrainingonautonomicandhemodynamicresponsestomusclemetaboreflexinpeoplelivingwithhivaidsarandomizedclinicaltrialprotocol
AT lopesgabrielladeoliveira theeffectsofexercisetrainingonautonomicandhemodynamicresponsestomusclemetaboreflexinpeoplelivingwithhivaidsarandomizedclinicaltrialprotocol
AT lopeskarynnegrutter theeffectsofexercisetrainingonautonomicandhemodynamicresponsestomusclemetaboreflexinpeoplelivingwithhivaidsarandomizedclinicaltrialprotocol
AT farinattipaulo theeffectsofexercisetrainingonautonomicandhemodynamicresponsestomusclemetaboreflexinpeoplelivingwithhivaidsarandomizedclinicaltrialprotocol
AT borgesjulianapereira theeffectsofexercisetrainingonautonomicandhemodynamicresponsestomusclemetaboreflexinpeoplelivingwithhivaidsarandomizedclinicaltrialprotocol
AT gamagabriel effectsofexercisetrainingonautonomicandhemodynamicresponsestomusclemetaboreflexinpeoplelivingwithhivaidsarandomizedclinicaltrialprotocol
AT dossantosrangelmarcusvinicius effectsofexercisetrainingonautonomicandhemodynamicresponsestomusclemetaboreflexinpeoplelivingwithhivaidsarandomizedclinicaltrialprotocol
AT deoliveiracoelhovanessacunha effectsofexercisetrainingonautonomicandhemodynamicresponsestomusclemetaboreflexinpeoplelivingwithhivaidsarandomizedclinicaltrialprotocol
AT pazgabrielaandrade effectsofexercisetrainingonautonomicandhemodynamicresponsestomusclemetaboreflexinpeoplelivingwithhivaidsarandomizedclinicaltrialprotocol
AT dematoscatarinavieirabranco effectsofexercisetrainingonautonomicandhemodynamicresponsestomusclemetaboreflexinpeoplelivingwithhivaidsarandomizedclinicaltrialprotocol
AT silvabarbarapinheiro effectsofexercisetrainingonautonomicandhemodynamicresponsestomusclemetaboreflexinpeoplelivingwithhivaidsarandomizedclinicaltrialprotocol
AT lopesgabrielladeoliveira effectsofexercisetrainingonautonomicandhemodynamicresponsestomusclemetaboreflexinpeoplelivingwithhivaidsarandomizedclinicaltrialprotocol
AT lopeskarynnegrutter effectsofexercisetrainingonautonomicandhemodynamicresponsestomusclemetaboreflexinpeoplelivingwithhivaidsarandomizedclinicaltrialprotocol
AT farinattipaulo effectsofexercisetrainingonautonomicandhemodynamicresponsestomusclemetaboreflexinpeoplelivingwithhivaidsarandomizedclinicaltrialprotocol
AT borgesjulianapereira effectsofexercisetrainingonautonomicandhemodynamicresponsestomusclemetaboreflexinpeoplelivingwithhivaidsarandomizedclinicaltrialprotocol