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Is large-scale rapid CoV-2 testing a substitute for lockdowns?

BACKGROUND: Various forms of contact restrictions have been adopted in response to the Covid-19 pandemic. Around February 2021, rapid testing appeared as a new policy instrument. Some claim it may serve as a substitute for contact restrictions. We study the strength of this argument by evaluating th...

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Autores principales: Diederichs, Marc, Glawion, René, Kremsner, Peter G., Mitze, Timo, Müller, Gernot J., Papies, Dominik, Schulz, Felix, Wälde, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8932588/
https://www.ncbi.nlm.nih.gov/pubmed/35302989
http://dx.doi.org/10.1371/journal.pone.0265207
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author Diederichs, Marc
Glawion, René
Kremsner, Peter G.
Mitze, Timo
Müller, Gernot J.
Papies, Dominik
Schulz, Felix
Wälde, Klaus
author_facet Diederichs, Marc
Glawion, René
Kremsner, Peter G.
Mitze, Timo
Müller, Gernot J.
Papies, Dominik
Schulz, Felix
Wälde, Klaus
author_sort Diederichs, Marc
collection PubMed
description BACKGROUND: Various forms of contact restrictions have been adopted in response to the Covid-19 pandemic. Around February 2021, rapid testing appeared as a new policy instrument. Some claim it may serve as a substitute for contact restrictions. We study the strength of this argument by evaluating the effects of a unique policy experiment: In March and April 2021, the city of Tübingen set up a testing scheme while relaxing contact restrictions. METHODS: We compare case rates in Tübingen county to an appropriately identified control unit. We employ the synthetic control method. We base interpretations of our findings on an extended SEIR model. FINDINGS: The experiment led to an increase in the reported case rate. This increase is robust across alternative statistical specifications. This is also due to more testing leading initially to more reported cases. An epidemiological model that corrects for ‘more cases due to more testing’ and ‘reduced testing and reporting during the Easter holiday’ confirms that the overall effect of the experiment led to more infections. INTERPRETATION: The number of rapid tests were not sufficiently high in this experiment to compensate for more contacts and thereby infections caused by relaxing contact restrictions.
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spelling pubmed-89325882022-03-19 Is large-scale rapid CoV-2 testing a substitute for lockdowns? Diederichs, Marc Glawion, René Kremsner, Peter G. Mitze, Timo Müller, Gernot J. Papies, Dominik Schulz, Felix Wälde, Klaus PLoS One Research Article BACKGROUND: Various forms of contact restrictions have been adopted in response to the Covid-19 pandemic. Around February 2021, rapid testing appeared as a new policy instrument. Some claim it may serve as a substitute for contact restrictions. We study the strength of this argument by evaluating the effects of a unique policy experiment: In March and April 2021, the city of Tübingen set up a testing scheme while relaxing contact restrictions. METHODS: We compare case rates in Tübingen county to an appropriately identified control unit. We employ the synthetic control method. We base interpretations of our findings on an extended SEIR model. FINDINGS: The experiment led to an increase in the reported case rate. This increase is robust across alternative statistical specifications. This is also due to more testing leading initially to more reported cases. An epidemiological model that corrects for ‘more cases due to more testing’ and ‘reduced testing and reporting during the Easter holiday’ confirms that the overall effect of the experiment led to more infections. INTERPRETATION: The number of rapid tests were not sufficiently high in this experiment to compensate for more contacts and thereby infections caused by relaxing contact restrictions. Public Library of Science 2022-03-18 /pmc/articles/PMC8932588/ /pubmed/35302989 http://dx.doi.org/10.1371/journal.pone.0265207 Text en © 2022 Diederichs et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Diederichs, Marc
Glawion, René
Kremsner, Peter G.
Mitze, Timo
Müller, Gernot J.
Papies, Dominik
Schulz, Felix
Wälde, Klaus
Is large-scale rapid CoV-2 testing a substitute for lockdowns?
title Is large-scale rapid CoV-2 testing a substitute for lockdowns?
title_full Is large-scale rapid CoV-2 testing a substitute for lockdowns?
title_fullStr Is large-scale rapid CoV-2 testing a substitute for lockdowns?
title_full_unstemmed Is large-scale rapid CoV-2 testing a substitute for lockdowns?
title_short Is large-scale rapid CoV-2 testing a substitute for lockdowns?
title_sort is large-scale rapid cov-2 testing a substitute for lockdowns?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8932588/
https://www.ncbi.nlm.nih.gov/pubmed/35302989
http://dx.doi.org/10.1371/journal.pone.0265207
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