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Structure of the Shaker Kv channel and mechanism of slow C-type inactivation

Voltage-activated potassium (Kv) channels open upon membrane depolarization and proceed to spontaneously inactivate. Inactivation controls neuronal firing rates and serves as a form of short-term memory and is implicated in various human neurological disorders. Here, we use high-resolution cryo–elec...

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Detalles Bibliográficos
Autores principales:	Tan, Xiao-Feng, Bae, Chanhyung, Stix, Robyn, Fernández-Mariño, Ana I., Huffer, Kate, Chang, Tsg-Hui, Jiang, Jiansen, Faraldo-Gómez, José D., Swartz, Kenton J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8932672/ https://www.ncbi.nlm.nih.gov/pubmed/35302848 http://dx.doi.org/10.1126/sciadv.abm7814

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