Cargando…

β1‐receptor polymorphisms and junctional ectopic tachycardia in children after cardiac surgery

Junctional ectopic tachycardia (JET) is a potentially life‐threatening postoperative arrhythmia in children with specific congenital heart defects and can contribute significantly to postoperative morbidity for at‐risk populations. In adults, β1‐adrenergic receptor (ADRB1) and β2‐adrenergic receptor...

Descripción completa

Detalles Bibliográficos
Autores principales: Dumeny, Leanne, Chantra, Marut, Langaee, Taimour, Duong, Benjamin Q., Zambrano, Daniel H., Han, Frank, Lopez‐Colon, Dalia, Humma, James F., Dacosta, Jonathan, Lovato, Tommie, Mei, Connie, Duarte, Julio D., Johnson, Julie A., Peek, Giles J., Jacobs, Jeffrey P., Bleiweis, Mark S., Cavallari, Larisa H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8932827/
https://www.ncbi.nlm.nih.gov/pubmed/34713976
http://dx.doi.org/10.1111/cts.13178
_version_ 1784671519027232768
author Dumeny, Leanne
Chantra, Marut
Langaee, Taimour
Duong, Benjamin Q.
Zambrano, Daniel H.
Han, Frank
Lopez‐Colon, Dalia
Humma, James F.
Dacosta, Jonathan
Lovato, Tommie
Mei, Connie
Duarte, Julio D.
Johnson, Julie A.
Peek, Giles J.
Jacobs, Jeffrey P.
Bleiweis, Mark S.
Cavallari, Larisa H.
author_facet Dumeny, Leanne
Chantra, Marut
Langaee, Taimour
Duong, Benjamin Q.
Zambrano, Daniel H.
Han, Frank
Lopez‐Colon, Dalia
Humma, James F.
Dacosta, Jonathan
Lovato, Tommie
Mei, Connie
Duarte, Julio D.
Johnson, Julie A.
Peek, Giles J.
Jacobs, Jeffrey P.
Bleiweis, Mark S.
Cavallari, Larisa H.
author_sort Dumeny, Leanne
collection PubMed
description Junctional ectopic tachycardia (JET) is a potentially life‐threatening postoperative arrhythmia in children with specific congenital heart defects and can contribute significantly to postoperative morbidity for at‐risk populations. In adults, β1‐adrenergic receptor (ADRB1) and β2‐adrenergic receptor (ADRB2) genotypes have been associated with increased risk for arrhythmias. However, their association with arrhythmia risk in children is unknown. We aimed to test associations between ADRB1 and ADRB2 genotypes and postoperative JET in patients with congenital heart defects. Children who underwent cardiac surgery were genotyped for the ADRB1 p.Ser49Gly (rs1801252; c.145A>G), p.Arg389Gly (rs1801253; c.1165C>G), ADRB2 p.Arg16Gly (rs1042713; c.46A>G), and p.Glu27Gln (rs1042714; c.79G>C) polymorphisms. The occurrence of postoperative JET was assessed via cardiologist‐interpreted electrocardiograms. Genotype associations with JET were analyzed via logistic regression, adjusted for clinical variables associated with JET, with separate analysis in patients not on a β‐blocker. Of the 343 children included (median age 8 months, 53% boys, 69% European ancestry), 45 (13%) developed JET. The Arg389Arg genotype was not significantly associated with JET in the overall population (odds ratio [OR] = 1.96, 95% confidence interval [CI] = 0.96–4.03, p = 0.064), but was nominally associated in patients not taking a β‐blocker (n = 324, OR = 2.25, 95% CI = 1.05–4.80. p = 0.034). None of the other variants were associated with JET. These data suggest that the ADRB1 Arg389Arg genotype may predict risk for JET following cardiac surgery in pediatric patients in the absence of β‐blockade. Whether treatment with a β‐blocker ameliorates this association requires further research.
format Online
Article
Text
id pubmed-8932827
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-89328272022-03-24 β1‐receptor polymorphisms and junctional ectopic tachycardia in children after cardiac surgery Dumeny, Leanne Chantra, Marut Langaee, Taimour Duong, Benjamin Q. Zambrano, Daniel H. Han, Frank Lopez‐Colon, Dalia Humma, James F. Dacosta, Jonathan Lovato, Tommie Mei, Connie Duarte, Julio D. Johnson, Julie A. Peek, Giles J. Jacobs, Jeffrey P. Bleiweis, Mark S. Cavallari, Larisa H. Clin Transl Sci Research Junctional ectopic tachycardia (JET) is a potentially life‐threatening postoperative arrhythmia in children with specific congenital heart defects and can contribute significantly to postoperative morbidity for at‐risk populations. In adults, β1‐adrenergic receptor (ADRB1) and β2‐adrenergic receptor (ADRB2) genotypes have been associated with increased risk for arrhythmias. However, their association with arrhythmia risk in children is unknown. We aimed to test associations between ADRB1 and ADRB2 genotypes and postoperative JET in patients with congenital heart defects. Children who underwent cardiac surgery were genotyped for the ADRB1 p.Ser49Gly (rs1801252; c.145A>G), p.Arg389Gly (rs1801253; c.1165C>G), ADRB2 p.Arg16Gly (rs1042713; c.46A>G), and p.Glu27Gln (rs1042714; c.79G>C) polymorphisms. The occurrence of postoperative JET was assessed via cardiologist‐interpreted electrocardiograms. Genotype associations with JET were analyzed via logistic regression, adjusted for clinical variables associated with JET, with separate analysis in patients not on a β‐blocker. Of the 343 children included (median age 8 months, 53% boys, 69% European ancestry), 45 (13%) developed JET. The Arg389Arg genotype was not significantly associated with JET in the overall population (odds ratio [OR] = 1.96, 95% confidence interval [CI] = 0.96–4.03, p = 0.064), but was nominally associated in patients not taking a β‐blocker (n = 324, OR = 2.25, 95% CI = 1.05–4.80. p = 0.034). None of the other variants were associated with JET. These data suggest that the ADRB1 Arg389Arg genotype may predict risk for JET following cardiac surgery in pediatric patients in the absence of β‐blockade. Whether treatment with a β‐blocker ameliorates this association requires further research. John Wiley and Sons Inc. 2021-11-05 2022-03 /pmc/articles/PMC8932827/ /pubmed/34713976 http://dx.doi.org/10.1111/cts.13178 Text en © 2021 The Authors. Clinical and Translational Science published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research
Dumeny, Leanne
Chantra, Marut
Langaee, Taimour
Duong, Benjamin Q.
Zambrano, Daniel H.
Han, Frank
Lopez‐Colon, Dalia
Humma, James F.
Dacosta, Jonathan
Lovato, Tommie
Mei, Connie
Duarte, Julio D.
Johnson, Julie A.
Peek, Giles J.
Jacobs, Jeffrey P.
Bleiweis, Mark S.
Cavallari, Larisa H.
β1‐receptor polymorphisms and junctional ectopic tachycardia in children after cardiac surgery
title β1‐receptor polymorphisms and junctional ectopic tachycardia in children after cardiac surgery
title_full β1‐receptor polymorphisms and junctional ectopic tachycardia in children after cardiac surgery
title_fullStr β1‐receptor polymorphisms and junctional ectopic tachycardia in children after cardiac surgery
title_full_unstemmed β1‐receptor polymorphisms and junctional ectopic tachycardia in children after cardiac surgery
title_short β1‐receptor polymorphisms and junctional ectopic tachycardia in children after cardiac surgery
title_sort β1‐receptor polymorphisms and junctional ectopic tachycardia in children after cardiac surgery
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8932827/
https://www.ncbi.nlm.nih.gov/pubmed/34713976
http://dx.doi.org/10.1111/cts.13178
work_keys_str_mv AT dumenyleanne b1receptorpolymorphismsandjunctionalectopictachycardiainchildrenaftercardiacsurgery
AT chantramarut b1receptorpolymorphismsandjunctionalectopictachycardiainchildrenaftercardiacsurgery
AT langaeetaimour b1receptorpolymorphismsandjunctionalectopictachycardiainchildrenaftercardiacsurgery
AT duongbenjaminq b1receptorpolymorphismsandjunctionalectopictachycardiainchildrenaftercardiacsurgery
AT zambranodanielh b1receptorpolymorphismsandjunctionalectopictachycardiainchildrenaftercardiacsurgery
AT hanfrank b1receptorpolymorphismsandjunctionalectopictachycardiainchildrenaftercardiacsurgery
AT lopezcolondalia b1receptorpolymorphismsandjunctionalectopictachycardiainchildrenaftercardiacsurgery
AT hummajamesf b1receptorpolymorphismsandjunctionalectopictachycardiainchildrenaftercardiacsurgery
AT dacostajonathan b1receptorpolymorphismsandjunctionalectopictachycardiainchildrenaftercardiacsurgery
AT lovatotommie b1receptorpolymorphismsandjunctionalectopictachycardiainchildrenaftercardiacsurgery
AT meiconnie b1receptorpolymorphismsandjunctionalectopictachycardiainchildrenaftercardiacsurgery
AT duartejuliod b1receptorpolymorphismsandjunctionalectopictachycardiainchildrenaftercardiacsurgery
AT johnsonjuliea b1receptorpolymorphismsandjunctionalectopictachycardiainchildrenaftercardiacsurgery
AT peekgilesj b1receptorpolymorphismsandjunctionalectopictachycardiainchildrenaftercardiacsurgery
AT jacobsjeffreyp b1receptorpolymorphismsandjunctionalectopictachycardiainchildrenaftercardiacsurgery
AT bleiweismarks b1receptorpolymorphismsandjunctionalectopictachycardiainchildrenaftercardiacsurgery
AT cavallarilarisah b1receptorpolymorphismsandjunctionalectopictachycardiainchildrenaftercardiacsurgery