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β1‐receptor polymorphisms and junctional ectopic tachycardia in children after cardiac surgery
Junctional ectopic tachycardia (JET) is a potentially life‐threatening postoperative arrhythmia in children with specific congenital heart defects and can contribute significantly to postoperative morbidity for at‐risk populations. In adults, β1‐adrenergic receptor (ADRB1) and β2‐adrenergic receptor...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8932827/ https://www.ncbi.nlm.nih.gov/pubmed/34713976 http://dx.doi.org/10.1111/cts.13178 |
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author | Dumeny, Leanne Chantra, Marut Langaee, Taimour Duong, Benjamin Q. Zambrano, Daniel H. Han, Frank Lopez‐Colon, Dalia Humma, James F. Dacosta, Jonathan Lovato, Tommie Mei, Connie Duarte, Julio D. Johnson, Julie A. Peek, Giles J. Jacobs, Jeffrey P. Bleiweis, Mark S. Cavallari, Larisa H. |
author_facet | Dumeny, Leanne Chantra, Marut Langaee, Taimour Duong, Benjamin Q. Zambrano, Daniel H. Han, Frank Lopez‐Colon, Dalia Humma, James F. Dacosta, Jonathan Lovato, Tommie Mei, Connie Duarte, Julio D. Johnson, Julie A. Peek, Giles J. Jacobs, Jeffrey P. Bleiweis, Mark S. Cavallari, Larisa H. |
author_sort | Dumeny, Leanne |
collection | PubMed |
description | Junctional ectopic tachycardia (JET) is a potentially life‐threatening postoperative arrhythmia in children with specific congenital heart defects and can contribute significantly to postoperative morbidity for at‐risk populations. In adults, β1‐adrenergic receptor (ADRB1) and β2‐adrenergic receptor (ADRB2) genotypes have been associated with increased risk for arrhythmias. However, their association with arrhythmia risk in children is unknown. We aimed to test associations between ADRB1 and ADRB2 genotypes and postoperative JET in patients with congenital heart defects. Children who underwent cardiac surgery were genotyped for the ADRB1 p.Ser49Gly (rs1801252; c.145A>G), p.Arg389Gly (rs1801253; c.1165C>G), ADRB2 p.Arg16Gly (rs1042713; c.46A>G), and p.Glu27Gln (rs1042714; c.79G>C) polymorphisms. The occurrence of postoperative JET was assessed via cardiologist‐interpreted electrocardiograms. Genotype associations with JET were analyzed via logistic regression, adjusted for clinical variables associated with JET, with separate analysis in patients not on a β‐blocker. Of the 343 children included (median age 8 months, 53% boys, 69% European ancestry), 45 (13%) developed JET. The Arg389Arg genotype was not significantly associated with JET in the overall population (odds ratio [OR] = 1.96, 95% confidence interval [CI] = 0.96–4.03, p = 0.064), but was nominally associated in patients not taking a β‐blocker (n = 324, OR = 2.25, 95% CI = 1.05–4.80. p = 0.034). None of the other variants were associated with JET. These data suggest that the ADRB1 Arg389Arg genotype may predict risk for JET following cardiac surgery in pediatric patients in the absence of β‐blockade. Whether treatment with a β‐blocker ameliorates this association requires further research. |
format | Online Article Text |
id | pubmed-8932827 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89328272022-03-24 β1‐receptor polymorphisms and junctional ectopic tachycardia in children after cardiac surgery Dumeny, Leanne Chantra, Marut Langaee, Taimour Duong, Benjamin Q. Zambrano, Daniel H. Han, Frank Lopez‐Colon, Dalia Humma, James F. Dacosta, Jonathan Lovato, Tommie Mei, Connie Duarte, Julio D. Johnson, Julie A. Peek, Giles J. Jacobs, Jeffrey P. Bleiweis, Mark S. Cavallari, Larisa H. Clin Transl Sci Research Junctional ectopic tachycardia (JET) is a potentially life‐threatening postoperative arrhythmia in children with specific congenital heart defects and can contribute significantly to postoperative morbidity for at‐risk populations. In adults, β1‐adrenergic receptor (ADRB1) and β2‐adrenergic receptor (ADRB2) genotypes have been associated with increased risk for arrhythmias. However, their association with arrhythmia risk in children is unknown. We aimed to test associations between ADRB1 and ADRB2 genotypes and postoperative JET in patients with congenital heart defects. Children who underwent cardiac surgery were genotyped for the ADRB1 p.Ser49Gly (rs1801252; c.145A>G), p.Arg389Gly (rs1801253; c.1165C>G), ADRB2 p.Arg16Gly (rs1042713; c.46A>G), and p.Glu27Gln (rs1042714; c.79G>C) polymorphisms. The occurrence of postoperative JET was assessed via cardiologist‐interpreted electrocardiograms. Genotype associations with JET were analyzed via logistic regression, adjusted for clinical variables associated with JET, with separate analysis in patients not on a β‐blocker. Of the 343 children included (median age 8 months, 53% boys, 69% European ancestry), 45 (13%) developed JET. The Arg389Arg genotype was not significantly associated with JET in the overall population (odds ratio [OR] = 1.96, 95% confidence interval [CI] = 0.96–4.03, p = 0.064), but was nominally associated in patients not taking a β‐blocker (n = 324, OR = 2.25, 95% CI = 1.05–4.80. p = 0.034). None of the other variants were associated with JET. These data suggest that the ADRB1 Arg389Arg genotype may predict risk for JET following cardiac surgery in pediatric patients in the absence of β‐blockade. Whether treatment with a β‐blocker ameliorates this association requires further research. John Wiley and Sons Inc. 2021-11-05 2022-03 /pmc/articles/PMC8932827/ /pubmed/34713976 http://dx.doi.org/10.1111/cts.13178 Text en © 2021 The Authors. Clinical and Translational Science published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Research Dumeny, Leanne Chantra, Marut Langaee, Taimour Duong, Benjamin Q. Zambrano, Daniel H. Han, Frank Lopez‐Colon, Dalia Humma, James F. Dacosta, Jonathan Lovato, Tommie Mei, Connie Duarte, Julio D. Johnson, Julie A. Peek, Giles J. Jacobs, Jeffrey P. Bleiweis, Mark S. Cavallari, Larisa H. β1‐receptor polymorphisms and junctional ectopic tachycardia in children after cardiac surgery |
title | β1‐receptor polymorphisms and junctional ectopic tachycardia in children after cardiac surgery |
title_full | β1‐receptor polymorphisms and junctional ectopic tachycardia in children after cardiac surgery |
title_fullStr | β1‐receptor polymorphisms and junctional ectopic tachycardia in children after cardiac surgery |
title_full_unstemmed | β1‐receptor polymorphisms and junctional ectopic tachycardia in children after cardiac surgery |
title_short | β1‐receptor polymorphisms and junctional ectopic tachycardia in children after cardiac surgery |
title_sort | β1‐receptor polymorphisms and junctional ectopic tachycardia in children after cardiac surgery |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8932827/ https://www.ncbi.nlm.nih.gov/pubmed/34713976 http://dx.doi.org/10.1111/cts.13178 |
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