Comprehensive engineering of a therapeutic neutralizing antibody targeting SARS-CoV-2 spike protein to neutralize escape variants

The emergence of escape variants of SARS-CoV-2 carrying mutations in the spike protein poses a challenge for therapeutic antibodies. Here, we show that through the comprehensive engineering of the variable region of the neutralizing monoclonal antibody 5A6, the engineered antibody, 5A6CCS1, is able...

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Detalles Bibliográficos
Autores principales: Kuramochi, Taichi, Gan, Siok Wan, Ho, Adrian W.S., Wang, Bei, Kageji, Nagisa, Nambu, Takeru, Iida, Sayaka, Okuda-Miura, Momoko, Chia, Wei Shan, Yeo, Chiew Ying, Chen, Dan, Lee, Wen-Hsin, Ngoh, Eve Zi Xian, Mohd Salleh, Siti Nazihah, Wang, Cheng-I, Igawa, Tomoyuki, Shimada, Hideaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8932922/
https://www.ncbi.nlm.nih.gov/pubmed/35293276
http://dx.doi.org/10.1080/19420862.2022.2040350

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