Diversely substituted sulfamides for fragment-based drug discovery of carbonic anhydrase inhibitors: synthesis and inhibitory profile

A series of sulfamide fragments has been synthesised and investigated for human carbonic anhydrase inhibition. One of the fragments showing greater selectivity for cancer-related isoforms hCA IX and XII was co-crystalized with hCA II showing significant potential for fragment periphery evolution via...

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Detalles Bibliográficos
Autores principales: Sharonova, Tatiana, Zhmurov, Petr, Kalinin, Stanislav, Nocentini, Alessio, Angeli, Andrea, Ferraroni, Marta, Korsakov, Mikhail, Supuran, Claudiu T., Krasavin, Mikhail
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933014/
https://www.ncbi.nlm.nih.gov/pubmed/35296197
http://dx.doi.org/10.1080/14756366.2022.2051023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933014/
https://www.ncbi.nlm.nih.gov/pubmed/35296197
http://dx.doi.org/10.1080/14756366.2022.2051023

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