6-Amino-2,4,5-trimethylpyridin-3-ol and 2-amino-4,6-dimethylpyrimidin-5-ol derivatives as selective fibroblast growth factor receptor 4 inhibitors: design, synthesis, molecular docking, and anti-hepatocellular carcinoma efficacy evaluation

A novel series of aminotrimethylpyridinol and aminodimethylpyrimidinol derivatives were designed and synthesised for FGFR4 inhibitors. Structure-activity relationship on the FGFR4 inhibitory activity of the new compounds was clearly elucidated by an intensive molecular docking study. Anti-cancer act...

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Detalles Bibliográficos
Autores principales: Chaudhary, Chhabi Lal, Lim, Dongchul, Chaudhary, Prakash, Guragain, Diwakar, Awasthi, Bhuwan Prasad, Park, Hee Dong, Kim, Jung-Ae, Jeong, Byeong-Seon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933034/
https://www.ncbi.nlm.nih.gov/pubmed/35296193
http://dx.doi.org/10.1080/14756366.2022.2048378

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933034/
https://www.ncbi.nlm.nih.gov/pubmed/35296193
http://dx.doi.org/10.1080/14756366.2022.2048378

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