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A Review of Bile Acid Metabolism and Signaling in Cognitive Dysfunction-Related Diseases

Bile acids are commonly known as one of the vital metabolites derived from cholesterol. The role of bile acids in glycolipid metabolism and their mechanisms in liver and cholestatic diseases have been well studied. In addition, bile acids also serve as ligands of signal molecules such as FXR, TGR5,...

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Autores principales: Weng, Ze-Bin, Chen, Yuan-Rong, Lv, Jin-Tao, Wang, Min-Xin, Chen, Zheng-Yuan, Zhou, Wen, Shen, Xin-Chun, Zhan, Li-Bin, Wang, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933076/
https://www.ncbi.nlm.nih.gov/pubmed/35308170
http://dx.doi.org/10.1155/2022/4289383
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author Weng, Ze-Bin
Chen, Yuan-Rong
Lv, Jin-Tao
Wang, Min-Xin
Chen, Zheng-Yuan
Zhou, Wen
Shen, Xin-Chun
Zhan, Li-Bin
Wang, Fang
author_facet Weng, Ze-Bin
Chen, Yuan-Rong
Lv, Jin-Tao
Wang, Min-Xin
Chen, Zheng-Yuan
Zhou, Wen
Shen, Xin-Chun
Zhan, Li-Bin
Wang, Fang
author_sort Weng, Ze-Bin
collection PubMed
description Bile acids are commonly known as one of the vital metabolites derived from cholesterol. The role of bile acids in glycolipid metabolism and their mechanisms in liver and cholestatic diseases have been well studied. In addition, bile acids also serve as ligands of signal molecules such as FXR, TGR5, and S1PR2 to regulate some physiological processes in vivo. Recent studies have found that bile acids signaling may also play a critical role in the central nervous system. Evidence showed that some bile acids have exhibited neuroprotective effects in experimental animal models and clinical trials of many cognitive dysfunction-related diseases. Besides, alterations in bile acid metabolisms well as the expression of different bile acid receptors have been discovered as possible biomarkers for prognosis tools in multiple cognitive dysfunction-related diseases. This review summarizes biosynthesis and regulation of bile acids, receptor classification and characteristics, receptor agonists and signaling transduction, and recent findings in cognitive dysfunction-related diseases.
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spelling pubmed-89330762022-03-19 A Review of Bile Acid Metabolism and Signaling in Cognitive Dysfunction-Related Diseases Weng, Ze-Bin Chen, Yuan-Rong Lv, Jin-Tao Wang, Min-Xin Chen, Zheng-Yuan Zhou, Wen Shen, Xin-Chun Zhan, Li-Bin Wang, Fang Oxid Med Cell Longev Review Article Bile acids are commonly known as one of the vital metabolites derived from cholesterol. The role of bile acids in glycolipid metabolism and their mechanisms in liver and cholestatic diseases have been well studied. In addition, bile acids also serve as ligands of signal molecules such as FXR, TGR5, and S1PR2 to regulate some physiological processes in vivo. Recent studies have found that bile acids signaling may also play a critical role in the central nervous system. Evidence showed that some bile acids have exhibited neuroprotective effects in experimental animal models and clinical trials of many cognitive dysfunction-related diseases. Besides, alterations in bile acid metabolisms well as the expression of different bile acid receptors have been discovered as possible biomarkers for prognosis tools in multiple cognitive dysfunction-related diseases. This review summarizes biosynthesis and regulation of bile acids, receptor classification and characteristics, receptor agonists and signaling transduction, and recent findings in cognitive dysfunction-related diseases. Hindawi 2022-03-11 /pmc/articles/PMC8933076/ /pubmed/35308170 http://dx.doi.org/10.1155/2022/4289383 Text en Copyright © 2022 Ze-Bin Weng et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Weng, Ze-Bin
Chen, Yuan-Rong
Lv, Jin-Tao
Wang, Min-Xin
Chen, Zheng-Yuan
Zhou, Wen
Shen, Xin-Chun
Zhan, Li-Bin
Wang, Fang
A Review of Bile Acid Metabolism and Signaling in Cognitive Dysfunction-Related Diseases
title A Review of Bile Acid Metabolism and Signaling in Cognitive Dysfunction-Related Diseases
title_full A Review of Bile Acid Metabolism and Signaling in Cognitive Dysfunction-Related Diseases
title_fullStr A Review of Bile Acid Metabolism and Signaling in Cognitive Dysfunction-Related Diseases
title_full_unstemmed A Review of Bile Acid Metabolism and Signaling in Cognitive Dysfunction-Related Diseases
title_short A Review of Bile Acid Metabolism and Signaling in Cognitive Dysfunction-Related Diseases
title_sort review of bile acid metabolism and signaling in cognitive dysfunction-related diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933076/
https://www.ncbi.nlm.nih.gov/pubmed/35308170
http://dx.doi.org/10.1155/2022/4289383
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