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A Review of Bile Acid Metabolism and Signaling in Cognitive Dysfunction-Related Diseases
Bile acids are commonly known as one of the vital metabolites derived from cholesterol. The role of bile acids in glycolipid metabolism and their mechanisms in liver and cholestatic diseases have been well studied. In addition, bile acids also serve as ligands of signal molecules such as FXR, TGR5,...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933076/ https://www.ncbi.nlm.nih.gov/pubmed/35308170 http://dx.doi.org/10.1155/2022/4289383 |
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author | Weng, Ze-Bin Chen, Yuan-Rong Lv, Jin-Tao Wang, Min-Xin Chen, Zheng-Yuan Zhou, Wen Shen, Xin-Chun Zhan, Li-Bin Wang, Fang |
author_facet | Weng, Ze-Bin Chen, Yuan-Rong Lv, Jin-Tao Wang, Min-Xin Chen, Zheng-Yuan Zhou, Wen Shen, Xin-Chun Zhan, Li-Bin Wang, Fang |
author_sort | Weng, Ze-Bin |
collection | PubMed |
description | Bile acids are commonly known as one of the vital metabolites derived from cholesterol. The role of bile acids in glycolipid metabolism and their mechanisms in liver and cholestatic diseases have been well studied. In addition, bile acids also serve as ligands of signal molecules such as FXR, TGR5, and S1PR2 to regulate some physiological processes in vivo. Recent studies have found that bile acids signaling may also play a critical role in the central nervous system. Evidence showed that some bile acids have exhibited neuroprotective effects in experimental animal models and clinical trials of many cognitive dysfunction-related diseases. Besides, alterations in bile acid metabolisms well as the expression of different bile acid receptors have been discovered as possible biomarkers for prognosis tools in multiple cognitive dysfunction-related diseases. This review summarizes biosynthesis and regulation of bile acids, receptor classification and characteristics, receptor agonists and signaling transduction, and recent findings in cognitive dysfunction-related diseases. |
format | Online Article Text |
id | pubmed-8933076 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-89330762022-03-19 A Review of Bile Acid Metabolism and Signaling in Cognitive Dysfunction-Related Diseases Weng, Ze-Bin Chen, Yuan-Rong Lv, Jin-Tao Wang, Min-Xin Chen, Zheng-Yuan Zhou, Wen Shen, Xin-Chun Zhan, Li-Bin Wang, Fang Oxid Med Cell Longev Review Article Bile acids are commonly known as one of the vital metabolites derived from cholesterol. The role of bile acids in glycolipid metabolism and their mechanisms in liver and cholestatic diseases have been well studied. In addition, bile acids also serve as ligands of signal molecules such as FXR, TGR5, and S1PR2 to regulate some physiological processes in vivo. Recent studies have found that bile acids signaling may also play a critical role in the central nervous system. Evidence showed that some bile acids have exhibited neuroprotective effects in experimental animal models and clinical trials of many cognitive dysfunction-related diseases. Besides, alterations in bile acid metabolisms well as the expression of different bile acid receptors have been discovered as possible biomarkers for prognosis tools in multiple cognitive dysfunction-related diseases. This review summarizes biosynthesis and regulation of bile acids, receptor classification and characteristics, receptor agonists and signaling transduction, and recent findings in cognitive dysfunction-related diseases. Hindawi 2022-03-11 /pmc/articles/PMC8933076/ /pubmed/35308170 http://dx.doi.org/10.1155/2022/4289383 Text en Copyright © 2022 Ze-Bin Weng et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Weng, Ze-Bin Chen, Yuan-Rong Lv, Jin-Tao Wang, Min-Xin Chen, Zheng-Yuan Zhou, Wen Shen, Xin-Chun Zhan, Li-Bin Wang, Fang A Review of Bile Acid Metabolism and Signaling in Cognitive Dysfunction-Related Diseases |
title | A Review of Bile Acid Metabolism and Signaling in Cognitive Dysfunction-Related Diseases |
title_full | A Review of Bile Acid Metabolism and Signaling in Cognitive Dysfunction-Related Diseases |
title_fullStr | A Review of Bile Acid Metabolism and Signaling in Cognitive Dysfunction-Related Diseases |
title_full_unstemmed | A Review of Bile Acid Metabolism and Signaling in Cognitive Dysfunction-Related Diseases |
title_short | A Review of Bile Acid Metabolism and Signaling in Cognitive Dysfunction-Related Diseases |
title_sort | review of bile acid metabolism and signaling in cognitive dysfunction-related diseases |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933076/ https://www.ncbi.nlm.nih.gov/pubmed/35308170 http://dx.doi.org/10.1155/2022/4289383 |
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