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Analysis of microvascular and neurodegenerative complications of mild COVID-19

PURPOSE: To examine retinal and corneal neurodegenerative and retinal microvascular changes in patients after mild or asymptomatic COVID-19 disease compared to age-matched controls. METHODS: Thirty-five (35) patients after PCR-proven SARS-CoV-2 infection and 28 age-matched controls were enrolled. Sw...

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Autores principales: Kolkedi, Zsofia, Csutak, Adrienne, Szalai, Eszter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933129/
https://www.ncbi.nlm.nih.gov/pubmed/35304621
http://dx.doi.org/10.1007/s00417-022-05623-8
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author Kolkedi, Zsofia
Csutak, Adrienne
Szalai, Eszter
author_facet Kolkedi, Zsofia
Csutak, Adrienne
Szalai, Eszter
author_sort Kolkedi, Zsofia
collection PubMed
description PURPOSE: To examine retinal and corneal neurodegenerative and retinal microvascular changes in patients after mild or asymptomatic COVID-19 disease compared to age-matched controls. METHODS: Thirty-five (35) patients after PCR-proven SARS-CoV-2 infection and 28 age-matched controls were enrolled. Swept-source optical coherence tomography (OCT), OCT angiography, and in vivo corneal confocal microscopy were performed in both groups. Corneal subbasal nerve plexus was quantified. Vessel density for superficial (SCP) and deep capillary plexus (DCP) and structural OCT parameters were recorded. RESULTS: Significantly lower nerve branch density (P = 0.0004), nerve fiber area (P = 0.0001), nerve fiber density (P = 0.0009), nerve fiber length (P < 0.0001), and total nerve branch density (P = 0.002) values were observed in patients after COVID-19 compared to healthy controls. VD of the temporal SCP was significantly different between the two groups (P = 0.019). No other SCP and DCP vessel density parameter differed significantly between the two groups. CONCLUSIONS: Our results suggest that peripheral neurodegenerative changes may occur even after mild or asymptomatic SARS-CoV-2 infection. No relevant microvascular changes were seen with OCT angiography and structural OCT parameters did not show any signs of optic neuropathy in post-COVID patients. In vivo confocal microscopy seems to be an important tool in monitoring peripheral neuropathy in patients after COVID-19.
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spelling pubmed-89331292022-03-21 Analysis of microvascular and neurodegenerative complications of mild COVID-19 Kolkedi, Zsofia Csutak, Adrienne Szalai, Eszter Graefes Arch Clin Exp Ophthalmol Inflammatory Disorders PURPOSE: To examine retinal and corneal neurodegenerative and retinal microvascular changes in patients after mild or asymptomatic COVID-19 disease compared to age-matched controls. METHODS: Thirty-five (35) patients after PCR-proven SARS-CoV-2 infection and 28 age-matched controls were enrolled. Swept-source optical coherence tomography (OCT), OCT angiography, and in vivo corneal confocal microscopy were performed in both groups. Corneal subbasal nerve plexus was quantified. Vessel density for superficial (SCP) and deep capillary plexus (DCP) and structural OCT parameters were recorded. RESULTS: Significantly lower nerve branch density (P = 0.0004), nerve fiber area (P = 0.0001), nerve fiber density (P = 0.0009), nerve fiber length (P < 0.0001), and total nerve branch density (P = 0.002) values were observed in patients after COVID-19 compared to healthy controls. VD of the temporal SCP was significantly different between the two groups (P = 0.019). No other SCP and DCP vessel density parameter differed significantly between the two groups. CONCLUSIONS: Our results suggest that peripheral neurodegenerative changes may occur even after mild or asymptomatic SARS-CoV-2 infection. No relevant microvascular changes were seen with OCT angiography and structural OCT parameters did not show any signs of optic neuropathy in post-COVID patients. In vivo confocal microscopy seems to be an important tool in monitoring peripheral neuropathy in patients after COVID-19. Springer Berlin Heidelberg 2022-03-19 2022 /pmc/articles/PMC8933129/ /pubmed/35304621 http://dx.doi.org/10.1007/s00417-022-05623-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Inflammatory Disorders
Kolkedi, Zsofia
Csutak, Adrienne
Szalai, Eszter
Analysis of microvascular and neurodegenerative complications of mild COVID-19
title Analysis of microvascular and neurodegenerative complications of mild COVID-19
title_full Analysis of microvascular and neurodegenerative complications of mild COVID-19
title_fullStr Analysis of microvascular and neurodegenerative complications of mild COVID-19
title_full_unstemmed Analysis of microvascular and neurodegenerative complications of mild COVID-19
title_short Analysis of microvascular and neurodegenerative complications of mild COVID-19
title_sort analysis of microvascular and neurodegenerative complications of mild covid-19
topic Inflammatory Disorders
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933129/
https://www.ncbi.nlm.nih.gov/pubmed/35304621
http://dx.doi.org/10.1007/s00417-022-05623-8
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