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Options in the Treatment of Subacute Sclerosing Panencephalitis: Implications for Low Resource Areas

PURPOSE OF THE REVIEW: Subacute sclerosing panencephalitis (SSPE) is a rare, slowly progressive, and frequently fatal neurodegenerative disorder caused by measles virus. The risk of SSPE remains significant globally, with fluctuating incidence noted in in tandem with measles vaccine uptake. This rev...

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Autores principales: Samia, Pauline, Oyieke, Katherine, Tunje, Dorcas, Udwadia-Hegde, Anaita, Feemster, Kristen, Oncel, Ibrahim, Anlar, Banu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933242/
https://www.ncbi.nlm.nih.gov/pubmed/35340572
http://dx.doi.org/10.1007/s11940-022-00710-x
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author Samia, Pauline
Oyieke, Katherine
Tunje, Dorcas
Udwadia-Hegde, Anaita
Feemster, Kristen
Oncel, Ibrahim
Anlar, Banu
author_facet Samia, Pauline
Oyieke, Katherine
Tunje, Dorcas
Udwadia-Hegde, Anaita
Feemster, Kristen
Oncel, Ibrahim
Anlar, Banu
author_sort Samia, Pauline
collection PubMed
description PURPOSE OF THE REVIEW: Subacute sclerosing panencephalitis (SSPE) is a rare, slowly progressive, and frequently fatal neurodegenerative disorder caused by measles virus. The risk of SSPE remains significant globally, with fluctuating incidence noted in in tandem with measles vaccine uptake. This review aims to explore the current global status of SSPE, its treatment, and preventive measures. RECENT FINDINGS: An increase in measles cases have been reported in various parts of the world for different reasons related to the regional context of the outbreak. With reduction in measles vaccine doses since the onset of the COVID-19 pandemic, the future risk of SSPE can only accelerate. In recent years, subsequent cases of SSPE have been reported in the period following documented measles outbreaks in different settings. Concomitantly, there have been efforts to evaluate the efficacy of immunomodulatory, antiviral, and anti-seizure therapies that could ameliorate the devastating effects of this disease. This review elucidates on these approaches and their limitations, reasons for poor vaccine coverage in low- and middle-income countries, as well as the possible solutions to the prevention of measles and eventual avoidance of SSPE. SUMMARY: Prevention of measles virus infection with the resultant sequelae would be the most effective strategy for the management of SSPE. This approach would be particularly important in low resource setting that currently bears the double burden of widespread communicable diseases and malnutrition.
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spelling pubmed-89332422022-03-21 Options in the Treatment of Subacute Sclerosing Panencephalitis: Implications for Low Resource Areas Samia, Pauline Oyieke, Katherine Tunje, Dorcas Udwadia-Hegde, Anaita Feemster, Kristen Oncel, Ibrahim Anlar, Banu Curr Treat Options Neurol Pediatric Neurology (A Yeshokumar, Section Editor) PURPOSE OF THE REVIEW: Subacute sclerosing panencephalitis (SSPE) is a rare, slowly progressive, and frequently fatal neurodegenerative disorder caused by measles virus. The risk of SSPE remains significant globally, with fluctuating incidence noted in in tandem with measles vaccine uptake. This review aims to explore the current global status of SSPE, its treatment, and preventive measures. RECENT FINDINGS: An increase in measles cases have been reported in various parts of the world for different reasons related to the regional context of the outbreak. With reduction in measles vaccine doses since the onset of the COVID-19 pandemic, the future risk of SSPE can only accelerate. In recent years, subsequent cases of SSPE have been reported in the period following documented measles outbreaks in different settings. Concomitantly, there have been efforts to evaluate the efficacy of immunomodulatory, antiviral, and anti-seizure therapies that could ameliorate the devastating effects of this disease. This review elucidates on these approaches and their limitations, reasons for poor vaccine coverage in low- and middle-income countries, as well as the possible solutions to the prevention of measles and eventual avoidance of SSPE. SUMMARY: Prevention of measles virus infection with the resultant sequelae would be the most effective strategy for the management of SSPE. This approach would be particularly important in low resource setting that currently bears the double burden of widespread communicable diseases and malnutrition. Springer US 2022-03-19 2022 /pmc/articles/PMC8933242/ /pubmed/35340572 http://dx.doi.org/10.1007/s11940-022-00710-x Text en © The Author(s) 2022, corrected publication 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Pediatric Neurology (A Yeshokumar, Section Editor)
Samia, Pauline
Oyieke, Katherine
Tunje, Dorcas
Udwadia-Hegde, Anaita
Feemster, Kristen
Oncel, Ibrahim
Anlar, Banu
Options in the Treatment of Subacute Sclerosing Panencephalitis: Implications for Low Resource Areas
title Options in the Treatment of Subacute Sclerosing Panencephalitis: Implications for Low Resource Areas
title_full Options in the Treatment of Subacute Sclerosing Panencephalitis: Implications for Low Resource Areas
title_fullStr Options in the Treatment of Subacute Sclerosing Panencephalitis: Implications for Low Resource Areas
title_full_unstemmed Options in the Treatment of Subacute Sclerosing Panencephalitis: Implications for Low Resource Areas
title_short Options in the Treatment of Subacute Sclerosing Panencephalitis: Implications for Low Resource Areas
title_sort options in the treatment of subacute sclerosing panencephalitis: implications for low resource areas
topic Pediatric Neurology (A Yeshokumar, Section Editor)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933242/
https://www.ncbi.nlm.nih.gov/pubmed/35340572
http://dx.doi.org/10.1007/s11940-022-00710-x
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