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Extravesicular TIMP-1 is a non-invasive independent prognostic marker and potential therapeutic target in colorectal liver metastases

Molecular reprogramming of stromal microarchitecture by tumour-derived extracellular vesicles (EVs) is proposed to favour pre-metastatic niche formation. We elucidated the role of extravesicular tissue inhibitor of matrix metalloproteinase-1 (TIMP1(EV)) in pro-invasive extracellular matrix (ECM) rem...

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Detalles Bibliográficos
Autores principales:	Rao, Venkatesh Sadananda, Gu, Qianyu, Tzschentke, Sandra, Lin, Kuailu, Ganig, Nicole, Thepkaysone, May-Linn, Wong, Fang Cheng, Polster, Heike, Seifert, Lena, Seifert, Adrian M., Buck, Nathalie, Riediger, Carina, Weiße, Jonas, Gutschner, Tony, Michen, Susanne, Temme, Achim, Schneider, Martin, Baenke, Franziska, Weitz, Jürgen, Kahlert, Christoph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933275/ https://www.ncbi.nlm.nih.gov/pubmed/35140332 http://dx.doi.org/10.1038/s41388-022-02218-9

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