Cargando…

The role of CD4 T cells in rejection of solid tumors

The focus in cancer immunotherapy has mainly been on CD8 T cells, as they can directly recognize cancer cells. CD4 T cells have largely been neglected, because most cancers lack MHC II expression and cannot directly be recognized by CD4 T cells. Yet, tumor antigens can be captured and cross-presente...

Descripción completa

Detalles Bibliográficos
Autores principales:	Poncette, Lucia, Bluhm, Julia, Blankenstein, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933281/ https://www.ncbi.nlm.nih.gov/pubmed/34619457 http://dx.doi.org/10.1016/j.coi.2021.09.005

Ejemplares similares

Generation of TGFβR2(-1) neoantigen-specific HLA-DR4-restricted T cell receptors for cancer therapy
por: Plewa, Natalia, et al.
Publicado: (2023)

The Roles of CD8(+) and CD4(+) Cells in Tumor Rejection
por: Udono, Heiichiro, et al.
Publicado: (1989)

Tumor Rejection by Modulation of Tumor Stromal Fibroblasts
por: Schüler, Thomas, et al.
Publicado: (2003)

Tumor Rejection by Disturbing Tumor Stroma Cell Interactions
por: Ibe, Sabrina, et al.
Publicado: (2001)

Human TCR-MHC coevolution after divergence from mice includes increased nontemplate-encoded CDR3 diversity
por: Chen, Xiaojing, et al.
Publicado: (2017)

Interleukin 7 induces CD4+ T cell-dependent tumor rejection
Publicado: (1991)

Intratumor depletion of CD4(+) cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors
por: Yu, Ping, et al.
Publicado: (2005)

Generation of Tumor-associated Cytotoxic T Lymphocytes Requires Interleukin 4 from CD8(+) T Cells
por: Schüler, Thomas, et al.
Publicado: (2001)

Spontaneous tumor rejection by cbl-b–deficient CD8(+) T cells
por: Loeser, Stefanie, et al.
Publicado: (2007)

Recombinant Listeria promotes tumor rejection by CD8(+) T cell-dependent remodeling of the tumor microenvironment
por: Deng, Weiwen, et al.
Publicado: (2018)

Xenogeneic skin graft rejection is especially dependent on CD4+ T cells
Publicado: (1989)

CD28 Co-Stimulus Achieves Superior CAR T Cell Effector Function against Solid Tumors Than 4-1BB Co-Stimulus
por: Textor, Ana, et al.
Publicado: (2021)

Rejection of benign melanocytic nevi by nevus-resident CD4(+) T cells
por: Schiferle, Erik B., et al.
Publicado: (2021)

A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy
por: Yuan, Xueli, et al.
Publicado: (2008)

Differential roles of Mac-1+ cells, and CD4+ and CD8+ T lymphocytes in primary nonfunction and classic rejection of islet allografts
Publicado: (1990)

Interleukin-7 Modulates Anti-Tumor CD8(+) T Cell Responses via Its Action on Host Cells
por: Deiser, Katrin, et al.
Publicado: (2016)

A direct comparison of rejection by CD8 and CD4 T cells in a transgenic model of allotransplantation
por: Porrett, Paige M., et al.
Publicado: (2008)

Tumor Rejection Induced by CD70-mediated Quantitative and Qualitative Effects on Effector CD8(+) T Cell Formation
por: Arens, Ramon, et al.
Publicado: (2004)

PD-1 and ICOS coexpression identifies tumor-reactive CD4(+) T cells in human solid tumors
por: Duhen, Rebekka, et al.
Publicado: (2022)

Depletion of B220(+)NK1.1(+) cells enhances the rejection of established melanoma by tumor-specific CD4(+) T cells
por: Wilson, Kyle A, et al.
Publicado: (2015)

The Roles of CD38 and CD157 in the Solid Tumor Microenvironment and Cancer Immunotherapy
por: Wo, Yu Jun, et al.
Publicado: (2019)

Human MHC Class I-restricted high avidity CD4(+) T cells generated by co-transfer of TCR and CD8 mediate efficient tumor rejection in vivo
por: Xue, Shao-An, et al.
Publicado: (2013)

Clinical significance of CD161(+)CD4(+) T cells in the development of chronic antibody-mediated rejection in kidney transplant recipients
por: Kim, Kyoung Woon, et al.
Publicado: (2018)

Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors
por: Duhen, Thomas, et al.
Publicado: (2018)

The Role of TLRs in Anti-cancer Immunity and Tumor Rejection
por: Urban-Wojciuk, Zuzanna, et al.
Publicado: (2019)

THE ROLE OF A NATURAL ANTIBODY IN THE REJECTION OF MOUSE TUMOR CELLS BY THE CHICK EMBRYO
por: Green, Howard, et al.
Publicado: (1957)

An Essential Role for Tumor Necrosis Factor in Natural Killer Cell–mediated Tumor Rejection in the Peritoneum
por: Smyth, Mark J., et al.
Publicado: (1998)

Vectorized Treg-depleting αCTLA-4 elicits antigen cross-presentation and CD8(+) T cell immunity to reject ‘cold’ tumors
por: Semmrich, Monika, et al.
Publicado: (2022)

CD4-CD8- T cell receptor alpha beta T cells: generation of an in vitro major histocompatibility complex class I specific cytotoxic T lymphocyte response and allogeneic tumor rejection
Publicado: (1991)

Effector CD4 and CD8 T Cells and Their Role in the Tumor Microenvironment
por: Hadrup, Sine, et al.
Publicado: (2012)

CTLA-4 blockade synergizes with cryoablation to mediate tumor rejection
por: Waitz, Rebecca, et al.
Publicado: (2012)

T Helper Cell Type 1–associated and Cytotoxic T Lymphocyte–mediated Tumor Immunity Is Impaired in Interleukin 4–deficient Mice
por: Schüler, Thomas, et al.
Publicado: (1999)

Mechanism of the rejection of major histocompatibility complex class I- disparate murine skin grafts: rejection can be mediated by CD4+ cells activated by allo-class I + II antigen in CD8+ cell-depleted hosts
Publicado: (1992)

Missing self triggers NK cell-mediated chronic vascular rejection of solid organ transplants
por: Koenig, Alice, et al.
Publicado: (2019)

A reassessment of the role of B7-1 expression in tumor rejection
Publicado: (1995)

Triptolide inhibits CD4(+) memory T cell-mediated acute rejection and prolongs cardiac allograft survival in mice
por: Qiu, Shuiwei, et al.
Publicado: (2017)

Low CD4/CD8 Ratio in Bronchus-Associated Lymphoid Tissue Is Associated with Lung Allograft Rejection
por: Shenoy, K. V., et al.
Publicado: (2012)

CD28 Family and Chronic Rejection: “To Belatacept...and Beyond!”
por: Silva, Marcos V., et al.
Publicado: (2012)

Interferon-γ Receptor Signaling in Dendritic Cells Restrains Spontaneous Proliferation of CD4(+) T Cells in Chronic Lymphopenic Mice
por: Knop, Laura, et al.
Publicado: (2019)

Checkpoint blockade in solid tumors and B-cell malignancies, with special consideration of the role of CD200
por: Gorczynski, Reginald M, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_i6a46aki6qeob5sguav4nv57p2