Testing preexisting antibodies prior to AAV gene transfer therapy: rationale, lessons and future considerations

Given the increasing number of gene transfer therapy studies either completed or underway, there is growing attention to the importance of preexisting adaptive immunity to the viral vectors used. The recombinant viral vectors developed for gene transfer therapy share structural features with natural...

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Detalles Bibliográficos
Autores principales: Mendell, Jerry R., Connolly, Anne M., Lehman, Kelly J., Griffin, Danielle A., Khan, Sohrab Z., Dharia, Sachi D., Quintana-Gallardo, Lucía, Rodino-Klapac, Louise R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933338/
https://www.ncbi.nlm.nih.gov/pubmed/35356756
http://dx.doi.org/10.1016/j.omtm.2022.02.011

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