N(7)-methylguanosine tRNA modification promotes esophageal squamous cell carcinoma tumorigenesis via the RPTOR/ULK1/autophagy axis

Mis-regulated RNA modifications promote the processing and translation of oncogenic mRNAs to facilitate cancer progression, while the molecular mechanisms remain unclear. Here we reveal that tRNA m(7)G methyltransferase complex proteins METTL1 and WDR4 are significantly up-regulated in esophageal sq...

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Detalles Bibliográficos
Autores principales: Han, Hui, Yang, Chunlong, Ma, Jieyi, Zhang, Shuishen, Zheng, Siyi, Ling, Rongsong, Sun, Kaiyu, Guo, Siyao, Huang, Boxuan, Liang, Yu, Wang, Lu, Chen, Shuang, Wang, Zhaoyu, Wei, Wei, Huang, Ying, Peng, Hao, Jiang, Yi-Zhou, Choe, Junho, Lin, Shuibin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933395/
https://www.ncbi.nlm.nih.gov/pubmed/35304469
http://dx.doi.org/10.1038/s41467-022-29125-7

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