Enhanced circulation longevity and pharmacodynamics of metformin from surface-modified nanostructured lipid carriers based on solidified reverse micellar solutions()

Metformin hydrochloride (MTH) has been associated with poor/incomplete absorption (50–60%), low bioavailability, short half-life (0.4–0.5 h), high dosage and dose-related side effects. To overcome these barriers and improve oral bioavailability and efficacy of MTH, surface-modified nanostructured li...

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Detalles Bibliográficos
Autores principales: Kenechukwu, Franklin Chimaobi, Isaac, God’spower Tochukwu, Nnamani, Daniel Okwudili, Momoh, Mumuni Audu, Attama, Anthony Amaechi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933683/
https://www.ncbi.nlm.nih.gov/pubmed/35313488
http://dx.doi.org/10.1016/j.heliyon.2022.e09100

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