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Navigating the ventricles: Novel insights into the pathogenesis of hydrocephalus
Congenital hydrocephalus occurs in one in 500–1000 babies born in the United States and acquired hydrocephalus may occur as the consequence of stroke, intraventricular and subarachnoid hemorrhage, traumatic brain injuries, brain tumors, craniectomy or may be idiopathic, as in the case of normal pres...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933686/ https://www.ncbi.nlm.nih.gov/pubmed/35306341 http://dx.doi.org/10.1016/j.ebiom.2022.103931 |
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author | Bramall, Alexa N. Anton, E.S. Kahle, Kristopher T. Fecci, Peter E. |
author_facet | Bramall, Alexa N. Anton, E.S. Kahle, Kristopher T. Fecci, Peter E. |
author_sort | Bramall, Alexa N. |
collection | PubMed |
description | Congenital hydrocephalus occurs in one in 500–1000 babies born in the United States and acquired hydrocephalus may occur as the consequence of stroke, intraventricular and subarachnoid hemorrhage, traumatic brain injuries, brain tumors, craniectomy or may be idiopathic, as in the case of normal pressure hydrocephalus. Irrespective of its prevalence and significant impact on quality of life, neurosurgeons still rely on invasive cerebrospinal fluid shunt systems for the treatment of hydrocephalus that are exceptionally prone to failure and/or infection. Further understanding of this process at a molecular level, therefore, may have profound implications for improving treatment and quality of life for millions of individuals worldwide. The purpose of this article is to review the current research landscape on hydrocephalus with a focus on recent advances in our understanding of cerebrospinal fluid pathways from an evolutionary, genetics and molecular perspective. |
format | Online Article Text |
id | pubmed-8933686 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-89336862022-03-20 Navigating the ventricles: Novel insights into the pathogenesis of hydrocephalus Bramall, Alexa N. Anton, E.S. Kahle, Kristopher T. Fecci, Peter E. EBioMedicine Review Congenital hydrocephalus occurs in one in 500–1000 babies born in the United States and acquired hydrocephalus may occur as the consequence of stroke, intraventricular and subarachnoid hemorrhage, traumatic brain injuries, brain tumors, craniectomy or may be idiopathic, as in the case of normal pressure hydrocephalus. Irrespective of its prevalence and significant impact on quality of life, neurosurgeons still rely on invasive cerebrospinal fluid shunt systems for the treatment of hydrocephalus that are exceptionally prone to failure and/or infection. Further understanding of this process at a molecular level, therefore, may have profound implications for improving treatment and quality of life for millions of individuals worldwide. The purpose of this article is to review the current research landscape on hydrocephalus with a focus on recent advances in our understanding of cerebrospinal fluid pathways from an evolutionary, genetics and molecular perspective. Elsevier 2022-03-17 /pmc/articles/PMC8933686/ /pubmed/35306341 http://dx.doi.org/10.1016/j.ebiom.2022.103931 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bramall, Alexa N. Anton, E.S. Kahle, Kristopher T. Fecci, Peter E. Navigating the ventricles: Novel insights into the pathogenesis of hydrocephalus |
title | Navigating the ventricles: Novel insights into the pathogenesis of hydrocephalus |
title_full | Navigating the ventricles: Novel insights into the pathogenesis of hydrocephalus |
title_fullStr | Navigating the ventricles: Novel insights into the pathogenesis of hydrocephalus |
title_full_unstemmed | Navigating the ventricles: Novel insights into the pathogenesis of hydrocephalus |
title_short | Navigating the ventricles: Novel insights into the pathogenesis of hydrocephalus |
title_sort | navigating the ventricles: novel insights into the pathogenesis of hydrocephalus |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933686/ https://www.ncbi.nlm.nih.gov/pubmed/35306341 http://dx.doi.org/10.1016/j.ebiom.2022.103931 |
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