Cargando…

PRMT5 regulates ATF4 transcript splicing and oxidative stress response

Protein methyltransferase 5 (PRMT5) symmetrically dimethylates arginine residues leading to regulation of transcription and splicing programs. Although PRMT5 has emerged as an attractive oncology target, the molecular determinants of PRMT5 dependency in cancer remain incompletely understood. Our tra...

Descripción completa

Detalles Bibliográficos
Autores principales:	Szewczyk, Magdalena M., Luciani, Genna M., Vu, Victoria, Murison, Alex, Dilworth, David, Barghout, Samir H., Lupien, Mathieu, Arrowsmith, Cheryl H., Minden, Mark D., Barsyte-Lovejoy, Dalia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933703/ https://www.ncbi.nlm.nih.gov/pubmed/35305370 http://dx.doi.org/10.1016/j.redox.2022.102282

Ejemplares similares

Structure and Function of Protein Arginine Methyltransferase PRMT7
por: Halabelian, Levon, et al.
Publicado: (2021)

PRMT5 inhibition disrupts splicing and stemness in glioblastoma
por: Sachamitr, Patty, et al.
Publicado: (2021)

Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells
por: Lima-Fernandes, Evelyne, et al.
Publicado: (2019)

Telomere dysfunction cooperates with epigenetic alterations to impair murine embryonic stem cell fate commitment
por: Criqui, Mélanie, et al.
Publicado: (2020)

PRMT inhibition induces a viral mimicry response in triple-negative breast cancer
por: Wu, Qin, et al.
Publicado: (2022)

Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response
por: Szewczyk, Magdalena M., et al.
Publicado: (2020)

Targeting human SET1/MLL family of proteins
por: Vedadi, Masoud, et al.
Publicado: (2017)

TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma
por: Nakayama, Kazuhide, et al.
Publicado: (2018)

Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3)
por: Kaniskan, H. Ümit, et al.
Publicado: (2017)

Author Correction: Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response
por: Szewczyk, Magdalena M., et al.
Publicado: (2020)

PRMT1 promotes neuroblastoma cell survival through ATF5
por: Hua, Zhong-Yan, et al.
Publicado: (2020)

Teneurin C-Terminal Associated Peptide (TCAP)-1 and Latrophilin Interaction in HEK293 Cells: Evidence for Modulation of Intercellular Adhesion
por: Husić, Mia, et al.
Publicado: (2019)

PRMT1 suppresses ATF4-mediated endoplasmic reticulum response in cardiomyocytes
por: Jeong, Myong-Ho, et al.
Publicado: (2019)

Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors
por: Dahlin, Jayme L., et al.
Publicado: (2017)

Correction: PRMT1 suppresses ATF4-mediated endoplasmic reticulum response in cardiomyocytes
por: Jeong, Myong-Ho, et al.
Publicado: (2020)

Discovery of a chemical probe for PRDM9
por: Allali-Hassani, Abdellah, et al.
Publicado: (2019)

A global assessment of cancer genomic alterations in epigenetic mechanisms
por: Shah, Muhammad A, et al.
Publicado: (2014)

Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family
por: Filippakopoulos, Panagis, et al.
Publicado: (2012)

Association of UHRF1 with H3K9 methylation directs the maintenance of DNA methylation
por: Rothbart, Scott B., et al.
Publicado: (2012)

Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex
por: Ivanochko, Danton, et al.
Publicado: (2019)

Distal extracellular teneurin region (teneurin C-terminal associated peptide; TCAP) possesses independent intracellular calcium regulating actions, in vitro: A potential antagonist of corticotropin-releasing factor (CRF)
por: Hogg, David W., et al.
Publicado: (2022)

Tumor suppressor BTG1 promotes PRMT1-mediated ATF4 function in response to cellular stress
por: Yuniati, Laurensia, et al.
Publicado: (2015)

Discovery and Characterization of BAY-805, a Potent and Selective Inhibitor of Ubiquitin-Specific Protease USP21
por: Göricke, Fabian, et al.
Publicado: (2023)

Prevalent p53 mutants co-opt chromatin pathways to drive cancer growth
por: Zhu, Jiajun, et al.
Publicado: (2015)

Discovery and Characterization of a Chemical Probe Targeting the Zinc-Finger Ubiquitin-Binding Domain of HDAC6
por: Harding, Rachel J., et al.
Publicado: (2023)

Mammary molecular portraits reveal lineage-specific features and progenitor cell vulnerabilities
por: Casey, Alison E., et al.
Publicado: (2018)

PRMT9 is a Type II methyltransferase that methylates the splicing factor SAP145
por: Yang, Yanzhong, et al.
Publicado: (2015)

PRMT1 loss sensitizes cells to PRMT5 inhibition
por: Gao, Guozhen, et al.
Publicado: (2019)

Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2
por: Eggert, Erik, et al.
Publicado: (2016)

PRMT5 and CDK4/6 inhibition result in distinctive patterns of alternative splicing in melanoma
por: Chan, Lok Hang, et al.
Publicado: (2023)

Synthetic Peptides as Therapeutic Agents: Lessons Learned From Evolutionary Ancient Peptides and Their Transit Across Blood-Brain Barriers
por: Lovejoy, David A., et al.
Publicado: (2019)

The chromatin and single-cell transcriptional landscapes of CD4 T cells in inflammatory bowel disease link risk loci with a proinflammatory Th17 cell population
por: Medina, Tiago S., et al.
Publicado: (2023)

The ubiquitin-activating enzyme, UBA1, as a novel therapeutic target for AML
por: Barghout, Samir H., et al.
Publicado: (2018)

Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing
por: Zhang, Li, et al.
Publicado: (2015)

The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer
por: Rengasamy, Madhumitha, et al.
Publicado: (2017)

PRMT5 methylome profiling uncovers a direct link to splicing regulation in acute myeloid leukemia
por: Radzisheuskaya, Aliaksandra, et al.
Publicado: (2019)

Protein arginine methyltransferases PRMT1, PRMT4/CARM1 and PRMT5 have distinct functions in control of osteoblast differentiation
por: Dashti, Parisa, et al.
Publicado: (2023)

PRMT1 Deficiency in Mouse Juvenile Heart Induces Dilated Cardiomyopathy and Reveals Cryptic Alternative Splicing Products
por: Murata, Kazuya, et al.
Publicado: (2018)

Profiling PRMT methylome reveals roles of hnRNPA1 arginine methylation in RNA splicing and cell growth
por: Li, Wen-juan, et al.
Publicado: (2021)

ATF linac commissioning
por: Hayano, H
Publicado: (1996)

Cannot write session to /tmp/vufind_sessions/sess_gro9otollc6t2vrcb812nt2udd