A case of thoracic air leak syndrome with pleural parenchymal fibroelastosis after treatment for hematologic malignancy while awaiting lung transplantation: Imaging and pathological findings of rapid loss in lung volume

We report the case of a 29-year-old man who underwent umbilical cord blood transplantation for chronic myelogenous leukemia 14 years previously. He was diagnosed with secondary pleuroparenchymal fibroelastosis (sPPFE) following treatment for hematologic malignancies (sPPFE after HM-Tx) 2.5 years ago...

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Autores principales: Kasai, Hajime, Terada, Jiro, Nagata, Jun, Yamamoto, Keiko, Shiohira, Shunya, Tomikawa, Atsuko, Tamura, Nao, Yamamoto, Emiri, Ikehara, Yuzuru, Suzuki, Takuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933706/
https://www.ncbi.nlm.nih.gov/pubmed/35313561
http://dx.doi.org/10.1016/j.rmcr.2022.101630
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author Kasai, Hajime
Terada, Jiro
Nagata, Jun
Yamamoto, Keiko
Shiohira, Shunya
Tomikawa, Atsuko
Tamura, Nao
Yamamoto, Emiri
Ikehara, Yuzuru
Suzuki, Takuji
author_facet Kasai, Hajime
Terada, Jiro
Nagata, Jun
Yamamoto, Keiko
Shiohira, Shunya
Tomikawa, Atsuko
Tamura, Nao
Yamamoto, Emiri
Ikehara, Yuzuru
Suzuki, Takuji
author_sort Kasai, Hajime
collection PubMed
description We report the case of a 29-year-old man who underwent umbilical cord blood transplantation for chronic myelogenous leukemia 14 years previously. He was diagnosed with secondary pleuroparenchymal fibroelastosis (sPPFE) following treatment for hematologic malignancies (sPPFE after HM-Tx) 2.5 years ago. On computed tomography, pleural thickening in the upper lobe, lung volume loss, and recurrent bilateral pneumothorax were detected. Although he waited for cadaveric lung transplantation (LTx) for 1.5 years, his respiratory failure worsened, and he died. Pathological autopsy and clinical course indicated sPPFE. After diagnosing sPPFE after HM-Tx, the timing for deciding LTx is critical, especially when pneumothorax recurs.
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spelling pubmed-89337062022-03-20 A case of thoracic air leak syndrome with pleural parenchymal fibroelastosis after treatment for hematologic malignancy while awaiting lung transplantation: Imaging and pathological findings of rapid loss in lung volume Kasai, Hajime Terada, Jiro Nagata, Jun Yamamoto, Keiko Shiohira, Shunya Tomikawa, Atsuko Tamura, Nao Yamamoto, Emiri Ikehara, Yuzuru Suzuki, Takuji Respir Med Case Rep Case Report We report the case of a 29-year-old man who underwent umbilical cord blood transplantation for chronic myelogenous leukemia 14 years previously. He was diagnosed with secondary pleuroparenchymal fibroelastosis (sPPFE) following treatment for hematologic malignancies (sPPFE after HM-Tx) 2.5 years ago. On computed tomography, pleural thickening in the upper lobe, lung volume loss, and recurrent bilateral pneumothorax were detected. Although he waited for cadaveric lung transplantation (LTx) for 1.5 years, his respiratory failure worsened, and he died. Pathological autopsy and clinical course indicated sPPFE. After diagnosing sPPFE after HM-Tx, the timing for deciding LTx is critical, especially when pneumothorax recurs. Elsevier 2022-03-14 /pmc/articles/PMC8933706/ /pubmed/35313561 http://dx.doi.org/10.1016/j.rmcr.2022.101630 Text en © 2022 The Authors. Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kasai, Hajime
Terada, Jiro
Nagata, Jun
Yamamoto, Keiko
Shiohira, Shunya
Tomikawa, Atsuko
Tamura, Nao
Yamamoto, Emiri
Ikehara, Yuzuru
Suzuki, Takuji
A case of thoracic air leak syndrome with pleural parenchymal fibroelastosis after treatment for hematologic malignancy while awaiting lung transplantation: Imaging and pathological findings of rapid loss in lung volume
title A case of thoracic air leak syndrome with pleural parenchymal fibroelastosis after treatment for hematologic malignancy while awaiting lung transplantation: Imaging and pathological findings of rapid loss in lung volume
title_full A case of thoracic air leak syndrome with pleural parenchymal fibroelastosis after treatment for hematologic malignancy while awaiting lung transplantation: Imaging and pathological findings of rapid loss in lung volume
title_fullStr A case of thoracic air leak syndrome with pleural parenchymal fibroelastosis after treatment for hematologic malignancy while awaiting lung transplantation: Imaging and pathological findings of rapid loss in lung volume
title_full_unstemmed A case of thoracic air leak syndrome with pleural parenchymal fibroelastosis after treatment for hematologic malignancy while awaiting lung transplantation: Imaging and pathological findings of rapid loss in lung volume
title_short A case of thoracic air leak syndrome with pleural parenchymal fibroelastosis after treatment for hematologic malignancy while awaiting lung transplantation: Imaging and pathological findings of rapid loss in lung volume
title_sort case of thoracic air leak syndrome with pleural parenchymal fibroelastosis after treatment for hematologic malignancy while awaiting lung transplantation: imaging and pathological findings of rapid loss in lung volume
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933706/
https://www.ncbi.nlm.nih.gov/pubmed/35313561
http://dx.doi.org/10.1016/j.rmcr.2022.101630
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