Cargando…

The quality of life in patients with Parkinson's disease: Focus on gender difference

BACKGROUND: To improve understanding of gender differences on quality of life (QoL) in patients with Parkinson's disease (PWP) of a different race, the differences of clinical features and health‐related quality of life (HRQoL) between male and female PWP were studied in a small cohort early to...

Descripción completa

Detalles Bibliográficos
Autores principales: Meng, Detao, Jin, Zhaohui, Gao, Lei, Wang, Yixuan, Wang, Ruidan, Fang, Jinping, Qi, Lin, Su, Yuan, Liu, Aixian, Fang, Boyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933778/
https://www.ncbi.nlm.nih.gov/pubmed/35138047
http://dx.doi.org/10.1002/brb3.2517
_version_ 1784671731055591424
author Meng, Detao
Jin, Zhaohui
Gao, Lei
Wang, Yixuan
Wang, Ruidan
Fang, Jinping
Qi, Lin
Su, Yuan
Liu, Aixian
Fang, Boyan
author_facet Meng, Detao
Jin, Zhaohui
Gao, Lei
Wang, Yixuan
Wang, Ruidan
Fang, Jinping
Qi, Lin
Su, Yuan
Liu, Aixian
Fang, Boyan
author_sort Meng, Detao
collection PubMed
description BACKGROUND: To improve understanding of gender differences on quality of life (QoL) in patients with Parkinson's disease (PWP) of a different race, the differences of clinical features and health‐related quality of life (HRQoL) between male and female PWP were studied in a small cohort early to middle stage of Chinese PWP. METHODS: A cross‐sectional study was carried out. PWP were consecutively included from April 2020 to July 2021 in Beijing Rehabilitation Hospital. HRQoL, motor symptoms, and nonmotor symptoms in each patient were evaluated. The differences of demographic, motor symptoms assessments, nonmotor symptoms assessments, and QoL between two gender groups were tested using t‐test statistics, Mann–Whitney–Wilcoxon test, or χ (2) depending on the data type. To eliminate the possible factors contributing to the QoL, linear regression models were constructed to sort out the effect of gender. RESULTS: One hundred and sixty‐two Parkinson's disease (PD) patients were included. Demographic, clinical characteristics, and symptom scale assessments had no statistical differences except for levodopa equivalent daily dose, Hamilton Anxiety Rating Score, REM sleep behavior disorder sleep questionnaire, and Hyposmia Rating Scale score. After baseline imbalance corrections, a significantly higher score of PD Questionnaire‐39 (PDQ‐39) in female than in male patients(p<.05) was found. In the questionnaire, summary Index and bodily discomfort, stigma, and emotional well‐being subscores were the main contribution differences. CONCLUSIONS: Gender differences are associated with the QoL in the early to middle stage PWP in China. Female patients have poorer QoL than male patients, especially bodily discomfort, stigma, and emotional well‐being.
format Online
Article
Text
id pubmed-8933778
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-89337782022-03-24 The quality of life in patients with Parkinson's disease: Focus on gender difference Meng, Detao Jin, Zhaohui Gao, Lei Wang, Yixuan Wang, Ruidan Fang, Jinping Qi, Lin Su, Yuan Liu, Aixian Fang, Boyan Brain Behav Original Articles BACKGROUND: To improve understanding of gender differences on quality of life (QoL) in patients with Parkinson's disease (PWP) of a different race, the differences of clinical features and health‐related quality of life (HRQoL) between male and female PWP were studied in a small cohort early to middle stage of Chinese PWP. METHODS: A cross‐sectional study was carried out. PWP were consecutively included from April 2020 to July 2021 in Beijing Rehabilitation Hospital. HRQoL, motor symptoms, and nonmotor symptoms in each patient were evaluated. The differences of demographic, motor symptoms assessments, nonmotor symptoms assessments, and QoL between two gender groups were tested using t‐test statistics, Mann–Whitney–Wilcoxon test, or χ (2) depending on the data type. To eliminate the possible factors contributing to the QoL, linear regression models were constructed to sort out the effect of gender. RESULTS: One hundred and sixty‐two Parkinson's disease (PD) patients were included. Demographic, clinical characteristics, and symptom scale assessments had no statistical differences except for levodopa equivalent daily dose, Hamilton Anxiety Rating Score, REM sleep behavior disorder sleep questionnaire, and Hyposmia Rating Scale score. After baseline imbalance corrections, a significantly higher score of PD Questionnaire‐39 (PDQ‐39) in female than in male patients(p<.05) was found. In the questionnaire, summary Index and bodily discomfort, stigma, and emotional well‐being subscores were the main contribution differences. CONCLUSIONS: Gender differences are associated with the QoL in the early to middle stage PWP in China. Female patients have poorer QoL than male patients, especially bodily discomfort, stigma, and emotional well‐being. John Wiley and Sons Inc. 2022-02-09 /pmc/articles/PMC8933778/ /pubmed/35138047 http://dx.doi.org/10.1002/brb3.2517 Text en © 2022 The Authors. Brain and Behavior published by Wiley Periodicals LLC https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Meng, Detao
Jin, Zhaohui
Gao, Lei
Wang, Yixuan
Wang, Ruidan
Fang, Jinping
Qi, Lin
Su, Yuan
Liu, Aixian
Fang, Boyan
The quality of life in patients with Parkinson's disease: Focus on gender difference
title The quality of life in patients with Parkinson's disease: Focus on gender difference
title_full The quality of life in patients with Parkinson's disease: Focus on gender difference
title_fullStr The quality of life in patients with Parkinson's disease: Focus on gender difference
title_full_unstemmed The quality of life in patients with Parkinson's disease: Focus on gender difference
title_short The quality of life in patients with Parkinson's disease: Focus on gender difference
title_sort quality of life in patients with parkinson's disease: focus on gender difference
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933778/
https://www.ncbi.nlm.nih.gov/pubmed/35138047
http://dx.doi.org/10.1002/brb3.2517
work_keys_str_mv AT mengdetao thequalityoflifeinpatientswithparkinsonsdiseasefocusongenderdifference
AT jinzhaohui thequalityoflifeinpatientswithparkinsonsdiseasefocusongenderdifference
AT gaolei thequalityoflifeinpatientswithparkinsonsdiseasefocusongenderdifference
AT wangyixuan thequalityoflifeinpatientswithparkinsonsdiseasefocusongenderdifference
AT wangruidan thequalityoflifeinpatientswithparkinsonsdiseasefocusongenderdifference
AT fangjinping thequalityoflifeinpatientswithparkinsonsdiseasefocusongenderdifference
AT qilin thequalityoflifeinpatientswithparkinsonsdiseasefocusongenderdifference
AT suyuan thequalityoflifeinpatientswithparkinsonsdiseasefocusongenderdifference
AT liuaixian thequalityoflifeinpatientswithparkinsonsdiseasefocusongenderdifference
AT fangboyan thequalityoflifeinpatientswithparkinsonsdiseasefocusongenderdifference
AT mengdetao qualityoflifeinpatientswithparkinsonsdiseasefocusongenderdifference
AT jinzhaohui qualityoflifeinpatientswithparkinsonsdiseasefocusongenderdifference
AT gaolei qualityoflifeinpatientswithparkinsonsdiseasefocusongenderdifference
AT wangyixuan qualityoflifeinpatientswithparkinsonsdiseasefocusongenderdifference
AT wangruidan qualityoflifeinpatientswithparkinsonsdiseasefocusongenderdifference
AT fangjinping qualityoflifeinpatientswithparkinsonsdiseasefocusongenderdifference
AT qilin qualityoflifeinpatientswithparkinsonsdiseasefocusongenderdifference
AT suyuan qualityoflifeinpatientswithparkinsonsdiseasefocusongenderdifference
AT liuaixian qualityoflifeinpatientswithparkinsonsdiseasefocusongenderdifference
AT fangboyan qualityoflifeinpatientswithparkinsonsdiseasefocusongenderdifference