A Point Mutation R122C in RUNX3 Promotes the Expansion of Isthmus Stem Cells and Inhibits Their Differentiation in the Stomach

BACKGROUND & AIMS: RUNX transcription factors play pivotal roles in embryonic development and neoplasia. We previously identified the single missense mutation R122C in RUNX3 from human gastric cancer. However, how RUNX3(R122C) mutation disrupts stem cell homeostasis and promotes gastric carcinog...

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Detalles Bibliográficos
Autores principales: Douchi, Daisuke, Yamamura, Akihiro, Matsuo, Junichi, Lee, Jung-Won, Nuttonmanit, Napat, Melissa Lim, Yi Hui, Suda, Kazuto, Shimura, Mitsuhiro, Chen, Sabirah, Pang, ShuChin, Kohu, Kazuyoshi, Kaneko, Mari, Kiyonari, Hiroshi, Kaneda, Atsushi, Yoshida, Hideyuki, Taniuchi, Ichiro, Osato, Motomi, Yang, Henry, Unno, Michiaki, Bok-Yan So, Jimmy, Yeoh, Khay Guan, Huey Chuang, Linda Shyue, Bae, Suk-Chul, Ito, Yoshiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933847/
https://www.ncbi.nlm.nih.gov/pubmed/35074568
http://dx.doi.org/10.1016/j.jcmgh.2022.01.010

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