Design, synthesis and biological evaluations of niclosamide analogues against SARS-CoV-2

Niclosamide, a widely-used anthelmintic drug, inhibits SARS-CoV-2 virus entry through TMEM16F inhibition and replication through autophagy induction, but the relatively high cytotoxicity and poor oral bioavailability limited its application. We synthesized 22 niclosamide analogues of which compound...

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Detalles Bibliográficos
Autores principales: Juang, Yu-Pu, Chou, Yu-Ting, Lin, Ru-Xian, Ma, Hsiu-Hua, Chao, Tai-Ling, Jan, Jia-Tsrong, Chang, Sui-Yuan, Liang, Pi-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Masson SAS. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933873/
https://www.ncbi.nlm.nih.gov/pubmed/35344901
http://dx.doi.org/10.1016/j.ejmech.2022.114295

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