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Periconceptional folic acid supplementation is a risk factor for childhood asthma: a case-control study

BACKGROUND: Several studies found an association between periconceptional folic acid supplementation and the risk of childhood asthma. But the epidemiologic evidence is still inconsistent and the underlying biological mechanisms remain unclear. METHODS: We conducted a hospital-based case-control stu...

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Autores principales: Chu, Shuyuan, Zhang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933875/
https://www.ncbi.nlm.nih.gov/pubmed/35303823
http://dx.doi.org/10.1186/s12884-022-04567-5
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author Chu, Shuyuan
Zhang, Jun
author_facet Chu, Shuyuan
Zhang, Jun
author_sort Chu, Shuyuan
collection PubMed
description BACKGROUND: Several studies found an association between periconceptional folic acid supplementation and the risk of childhood asthma. But the epidemiologic evidence is still inconsistent and the underlying biological mechanisms remain unclear. METHODS: We conducted a hospital-based case-control study on childhood asthma with 548 cases and 816 normal controls in Shanghai, China. Mothers of the asthma children were asked about folic acid supplementation before and during pregnancy. Unconditional logistic regression models were employed to control for potential confounders. RESULTS: Periconceptional folic acid supplementation was associated with an increased risk of childhood asthma after adjusting for potential confounders (adjusted OR = 1.28 [95% CI 1.14–1.43]). Moreover, the adjusted OR varied by the timing of starting folic acid supplementation: before gestation: 1.31 [95% CI 1.01–1.70]; in the 1st month of gestation: 1.09 [95% CI 0.96–1.23]; and after the 1st month of gestation: 1.90 [95% CI 1.56–2.30]. We further found that the adjusted OR was the highest when periconceptional folic acid supplementation lasted more than 6 months (< 4 months: 1.21 [95% CI 1.07–1.37]; 4–6 months: 1.06 [95% CI 0.88–1.27]; > 6 months: 1.75 [95% CI 1.35–2.27]). CONCLUSIONS: Periconceptional folic acid supplementation was associated with an increased risk of childhood asthma in offspring. Further research on this issue is warranted.
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spelling pubmed-89338752022-03-23 Periconceptional folic acid supplementation is a risk factor for childhood asthma: a case-control study Chu, Shuyuan Zhang, Jun BMC Pregnancy Childbirth Research BACKGROUND: Several studies found an association between periconceptional folic acid supplementation and the risk of childhood asthma. But the epidemiologic evidence is still inconsistent and the underlying biological mechanisms remain unclear. METHODS: We conducted a hospital-based case-control study on childhood asthma with 548 cases and 816 normal controls in Shanghai, China. Mothers of the asthma children were asked about folic acid supplementation before and during pregnancy. Unconditional logistic regression models were employed to control for potential confounders. RESULTS: Periconceptional folic acid supplementation was associated with an increased risk of childhood asthma after adjusting for potential confounders (adjusted OR = 1.28 [95% CI 1.14–1.43]). Moreover, the adjusted OR varied by the timing of starting folic acid supplementation: before gestation: 1.31 [95% CI 1.01–1.70]; in the 1st month of gestation: 1.09 [95% CI 0.96–1.23]; and after the 1st month of gestation: 1.90 [95% CI 1.56–2.30]. We further found that the adjusted OR was the highest when periconceptional folic acid supplementation lasted more than 6 months (< 4 months: 1.21 [95% CI 1.07–1.37]; 4–6 months: 1.06 [95% CI 0.88–1.27]; > 6 months: 1.75 [95% CI 1.35–2.27]). CONCLUSIONS: Periconceptional folic acid supplementation was associated with an increased risk of childhood asthma in offspring. Further research on this issue is warranted. BioMed Central 2022-03-18 /pmc/articles/PMC8933875/ /pubmed/35303823 http://dx.doi.org/10.1186/s12884-022-04567-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Chu, Shuyuan
Zhang, Jun
Periconceptional folic acid supplementation is a risk factor for childhood asthma: a case-control study
title Periconceptional folic acid supplementation is a risk factor for childhood asthma: a case-control study
title_full Periconceptional folic acid supplementation is a risk factor for childhood asthma: a case-control study
title_fullStr Periconceptional folic acid supplementation is a risk factor for childhood asthma: a case-control study
title_full_unstemmed Periconceptional folic acid supplementation is a risk factor for childhood asthma: a case-control study
title_short Periconceptional folic acid supplementation is a risk factor for childhood asthma: a case-control study
title_sort periconceptional folic acid supplementation is a risk factor for childhood asthma: a case-control study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933875/
https://www.ncbi.nlm.nih.gov/pubmed/35303823
http://dx.doi.org/10.1186/s12884-022-04567-5
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