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Toxoplasma gondii is not an important contributor to poor reproductive performance of primiparous ewes from southern Australia: a prospective cohort study

BACKGROUND: Toxoplasma gondii causes reproductive losses in sheep worldwide, including Australia. The reproductive performance of primiparous ewes is typically lower than for mature, multiparous ewes, and younger ewes are more likely to be immunologically naïve and therefore more susceptible to repr...

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Autores principales: Clune, Thomas, Lockwood, Amy, Hancock, Serina, Thompson, Andrew N., Bruce, Mieghan, Beetson, Sue, Campbell, Angus J., Glanville, Elsa, Brookes, Daniel, Trengove, Colin, O’Handley, Ryan, Jacobson, Caroline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933891/
https://www.ncbi.nlm.nih.gov/pubmed/35305646
http://dx.doi.org/10.1186/s12917-022-03211-w
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author Clune, Thomas
Lockwood, Amy
Hancock, Serina
Thompson, Andrew N.
Bruce, Mieghan
Beetson, Sue
Campbell, Angus J.
Glanville, Elsa
Brookes, Daniel
Trengove, Colin
O’Handley, Ryan
Jacobson, Caroline
author_facet Clune, Thomas
Lockwood, Amy
Hancock, Serina
Thompson, Andrew N.
Bruce, Mieghan
Beetson, Sue
Campbell, Angus J.
Glanville, Elsa
Brookes, Daniel
Trengove, Colin
O’Handley, Ryan
Jacobson, Caroline
author_sort Clune, Thomas
collection PubMed
description BACKGROUND: Toxoplasma gondii causes reproductive losses in sheep worldwide, including Australia. The reproductive performance of primiparous ewes is typically lower than for mature, multiparous ewes, and younger ewes are more likely to be immunologically naïve and therefore more susceptible to reproductive disease if T. gondii infection occurs during pregnancy. The aim of this study was to assess the impact of infection with T. gondii on the reproductive performance of primiparous ewes in southern Australia using a prospective cohort study. This will inform the need for targeted control strategies for T. gondii in Australian sheep. RESULTS: Toxoplasma gondii seropositivity using indirect ELISA was detected at 16/28 farms located across southern Australia. Apparent seropositivity to T. gondii was lower in primiparous ewes (1.1, 95% confidence interval (CI) 0.6, 1.8) compared to mature, multiparous ewes (8.1, 95% CI 6.0, 10.5; P < 0.001). Toxoplasma gondii seroconversion during the gestation and lambing period was confirmed for 11/1097 (1.0, 95% CI 0.5, 1.7) of pregnant primiparous ewes that failed to raise a lamb, and 1/161 (0.6, 95% CI 0.1, 2.9) primiparous ewes with confirmed mid-pregnancy abortion. CONCLUSIONS: Low frequency of detection of T. gondii seroconversion during gestation and low frequency of seropositivity to T. gondii suggests that toxoplasmosis was not an important contributor to reproductive losses in primiparous ewes on farms located over a wide geographical area in southern Australia. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12917-022-03211-w.
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spelling pubmed-89338912022-03-23 Toxoplasma gondii is not an important contributor to poor reproductive performance of primiparous ewes from southern Australia: a prospective cohort study Clune, Thomas Lockwood, Amy Hancock, Serina Thompson, Andrew N. Bruce, Mieghan Beetson, Sue Campbell, Angus J. Glanville, Elsa Brookes, Daniel Trengove, Colin O’Handley, Ryan Jacobson, Caroline BMC Vet Res Research BACKGROUND: Toxoplasma gondii causes reproductive losses in sheep worldwide, including Australia. The reproductive performance of primiparous ewes is typically lower than for mature, multiparous ewes, and younger ewes are more likely to be immunologically naïve and therefore more susceptible to reproductive disease if T. gondii infection occurs during pregnancy. The aim of this study was to assess the impact of infection with T. gondii on the reproductive performance of primiparous ewes in southern Australia using a prospective cohort study. This will inform the need for targeted control strategies for T. gondii in Australian sheep. RESULTS: Toxoplasma gondii seropositivity using indirect ELISA was detected at 16/28 farms located across southern Australia. Apparent seropositivity to T. gondii was lower in primiparous ewes (1.1, 95% confidence interval (CI) 0.6, 1.8) compared to mature, multiparous ewes (8.1, 95% CI 6.0, 10.5; P < 0.001). Toxoplasma gondii seroconversion during the gestation and lambing period was confirmed for 11/1097 (1.0, 95% CI 0.5, 1.7) of pregnant primiparous ewes that failed to raise a lamb, and 1/161 (0.6, 95% CI 0.1, 2.9) primiparous ewes with confirmed mid-pregnancy abortion. CONCLUSIONS: Low frequency of detection of T. gondii seroconversion during gestation and low frequency of seropositivity to T. gondii suggests that toxoplasmosis was not an important contributor to reproductive losses in primiparous ewes on farms located over a wide geographical area in southern Australia. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12917-022-03211-w. BioMed Central 2022-03-19 /pmc/articles/PMC8933891/ /pubmed/35305646 http://dx.doi.org/10.1186/s12917-022-03211-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Clune, Thomas
Lockwood, Amy
Hancock, Serina
Thompson, Andrew N.
Bruce, Mieghan
Beetson, Sue
Campbell, Angus J.
Glanville, Elsa
Brookes, Daniel
Trengove, Colin
O’Handley, Ryan
Jacobson, Caroline
Toxoplasma gondii is not an important contributor to poor reproductive performance of primiparous ewes from southern Australia: a prospective cohort study
title Toxoplasma gondii is not an important contributor to poor reproductive performance of primiparous ewes from southern Australia: a prospective cohort study
title_full Toxoplasma gondii is not an important contributor to poor reproductive performance of primiparous ewes from southern Australia: a prospective cohort study
title_fullStr Toxoplasma gondii is not an important contributor to poor reproductive performance of primiparous ewes from southern Australia: a prospective cohort study
title_full_unstemmed Toxoplasma gondii is not an important contributor to poor reproductive performance of primiparous ewes from southern Australia: a prospective cohort study
title_short Toxoplasma gondii is not an important contributor to poor reproductive performance of primiparous ewes from southern Australia: a prospective cohort study
title_sort toxoplasma gondii is not an important contributor to poor reproductive performance of primiparous ewes from southern australia: a prospective cohort study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933891/
https://www.ncbi.nlm.nih.gov/pubmed/35305646
http://dx.doi.org/10.1186/s12917-022-03211-w
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