KRAS acting through ERK signaling stabilizes PD-L1 via inhibiting autophagy pathway in intrahepatic cholangiocarcinoma

BACKGROUND: While the correlation between PD-L1 expression and KRAS mutation has been previously reported in other solid tumors such as non-small cell lung cancer (NSCLC), whether PD-L1 can be modulated by ERK signaling downstream of KRAS in intrahepatic cholangiocarcinoma (iCCA) and the underlying...

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Detalles Bibliográficos
Autores principales: Gao, Zheng, Chen, Jia-Feng, Li, Xiao-Gang, Shi, Ying-Hong, Tang, Zheng, Liu, Wei-Ren, Zhang, Xin, Huang, Ao, Luo, Xuan-Ming, Gao, Qiang, Shi, Guo-Ming, Ke, Ai-Wu, Zhou, Jian, Fan, Jia, Fu, Xiu-Tao, Ding, Zhen-Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933925/
https://www.ncbi.nlm.nih.gov/pubmed/35305624
http://dx.doi.org/10.1186/s12935-022-02550-w

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