Remdesivir-Associated Sinus Arrest in COVID-19: A Potential Indication for Close Cardiac Monitoring

Remdesivir is an antiviral, nucleoside analog used extensively during the coronavirus-disease 2019 (COVID-19) pandemic with proven efficacy against COVID-19-induced acute respiratory distress syndrome (ARDS). Our case report details the clinical course of a 50-year-old, COVID-19-positive patient who...

Descripción completa

Detalles Bibliográficos
Autores principales: Gregory, Grant E, Gregory, Hannah M, Liaqat, Hamza, Ghaly, Mina M, Johnson-Pich, Kristy D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934108/
https://www.ncbi.nlm.nih.gov/pubmed/35317046
http://dx.doi.org/10.7759/cureus.22328
_version_ 1784671791889776640
author Gregory, Grant E
Gregory, Hannah M
Liaqat, Hamza
Ghaly, Mina M
Johnson-Pich, Kristy D
author_facet Gregory, Grant E
Gregory, Hannah M
Liaqat, Hamza
Ghaly, Mina M
Johnson-Pich, Kristy D
author_sort Gregory, Grant E
collection PubMed
description Remdesivir is an antiviral, nucleoside analog used extensively during the coronavirus-disease 2019 (COVID-19) pandemic with proven efficacy against COVID-19-induced acute respiratory distress syndrome (ARDS). Our case report details the clinical course of a 50-year-old, COVID-19-positive patient who developed sinus arrest after being treated with remdesivir. Within 24 hours of discontinuing remdesivir therapy, the patient’s sinus arrest resolved to a normal sinus rhythm. The findings from our case report add to a growing body of evidence on the cardiotoxic profile of remdesivir. Remdesivir’s ability to cause bradyarrhythmias, and specifically sinus arrest, should be acknowledged when considering the use of this drug in at-risk patients.
format Online
Article
Text
id pubmed-8934108
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Cureus
record_format MEDLINE/PubMed
spelling pubmed-89341082022-03-21 Remdesivir-Associated Sinus Arrest in COVID-19: A Potential Indication for Close Cardiac Monitoring Gregory, Grant E Gregory, Hannah M Liaqat, Hamza Ghaly, Mina M Johnson-Pich, Kristy D Cureus Internal Medicine Remdesivir is an antiviral, nucleoside analog used extensively during the coronavirus-disease 2019 (COVID-19) pandemic with proven efficacy against COVID-19-induced acute respiratory distress syndrome (ARDS). Our case report details the clinical course of a 50-year-old, COVID-19-positive patient who developed sinus arrest after being treated with remdesivir. Within 24 hours of discontinuing remdesivir therapy, the patient’s sinus arrest resolved to a normal sinus rhythm. The findings from our case report add to a growing body of evidence on the cardiotoxic profile of remdesivir. Remdesivir’s ability to cause bradyarrhythmias, and specifically sinus arrest, should be acknowledged when considering the use of this drug in at-risk patients. Cureus 2022-02-17 /pmc/articles/PMC8934108/ /pubmed/35317046 http://dx.doi.org/10.7759/cureus.22328 Text en Copyright © 2022, Gregory et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Gregory, Grant E
Gregory, Hannah M
Liaqat, Hamza
Ghaly, Mina M
Johnson-Pich, Kristy D
Remdesivir-Associated Sinus Arrest in COVID-19: A Potential Indication for Close Cardiac Monitoring
title Remdesivir-Associated Sinus Arrest in COVID-19: A Potential Indication for Close Cardiac Monitoring
title_full Remdesivir-Associated Sinus Arrest in COVID-19: A Potential Indication for Close Cardiac Monitoring
title_fullStr Remdesivir-Associated Sinus Arrest in COVID-19: A Potential Indication for Close Cardiac Monitoring
title_full_unstemmed Remdesivir-Associated Sinus Arrest in COVID-19: A Potential Indication for Close Cardiac Monitoring
title_short Remdesivir-Associated Sinus Arrest in COVID-19: A Potential Indication for Close Cardiac Monitoring
title_sort remdesivir-associated sinus arrest in covid-19: a potential indication for close cardiac monitoring
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934108/
https://www.ncbi.nlm.nih.gov/pubmed/35317046
http://dx.doi.org/10.7759/cureus.22328
work_keys_str_mv AT gregorygrante remdesivirassociatedsinusarrestincovid19apotentialindicationforclosecardiacmonitoring
AT gregoryhannahm remdesivirassociatedsinusarrestincovid19apotentialindicationforclosecardiacmonitoring
AT liaqathamza remdesivirassociatedsinusarrestincovid19apotentialindicationforclosecardiacmonitoring
AT ghalyminam remdesivirassociatedsinusarrestincovid19apotentialindicationforclosecardiacmonitoring
AT johnsonpichkristyd remdesivirassociatedsinusarrestincovid19apotentialindicationforclosecardiacmonitoring

Ejemplares similares