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Waning effectiveness of CoronaVac in real life: A retrospective cohort study in health care workers
BACKGROUND: Real-world studies showed varying levels of effectiveness of CoronaVac vaccine against COVID-19 disease. This study aimed to assess the association between the vaccination with CoronaVac and the COVID-19 infections among the health care workers in a university hospital and to determine t...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Ltd.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934134/ https://www.ncbi.nlm.nih.gov/pubmed/35317942 http://dx.doi.org/10.1016/j.vaccine.2022.03.032 |
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author | Can, Gunay Acar, Hazal Cansu Aydin, Sumeyye Nur Balkan, Ilker Inanc Karaali, Ridvan Budak, Beyhan Saltoglu, Nese |
author_facet | Can, Gunay Acar, Hazal Cansu Aydin, Sumeyye Nur Balkan, Ilker Inanc Karaali, Ridvan Budak, Beyhan Saltoglu, Nese |
author_sort | Can, Gunay |
collection | PubMed |
description | BACKGROUND: Real-world studies showed varying levels of effectiveness of CoronaVac vaccine against COVID-19 disease. This study aimed to assess the association between the vaccination with CoronaVac and the COVID-19 infections among the health care workers in a university hospital and to determine the vaccine effectiveness against COVID-19 in a period when alpha variant was dominant. METHODS: This retrospective cohort study was conducted in a university hospital in Istanbul, Turkey employs 4067 health care workers. The follow-up period was defined as starting 14 days after receiving the second dose for fully vaccinated group. Health care workers were censored when have a positive PCR test result or at the end of the study. Unvaccinated health care workers were censored if they receive any COVID-19 vaccine doses. The incidence rate ratio and Cox regression were used to estimate the unadjusted and adjusted effectiveness of the vaccine. Findings: Seventy-one percent of the health care workers were fully vaccinated whereas 29% percent did not receive any doses. The incidence rate of SARS-CoV-2 infection was 133.7 vs 70.7 per 100.000 person-days in the unvaccinated and fully vaccinated groups, respectively. The unadjusted effectiveness against COVID-19 infection was 47% (95% CI 31–59%) whereas adjusted effectiveness was 39% (95% CI 20–64%). Interpretation: This real life study conducted in health care workers demonstrated that the effectiveness of two doses of the CoronaVac vaccine (39%) was lower than that determined in clinical trials. Due to reduce in protection over time or against variants, booster doses may be needed. |
format | Online Article Text |
id | pubmed-8934134 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89341342022-03-21 Waning effectiveness of CoronaVac in real life: A retrospective cohort study in health care workers Can, Gunay Acar, Hazal Cansu Aydin, Sumeyye Nur Balkan, Ilker Inanc Karaali, Ridvan Budak, Beyhan Saltoglu, Nese Vaccine Article BACKGROUND: Real-world studies showed varying levels of effectiveness of CoronaVac vaccine against COVID-19 disease. This study aimed to assess the association between the vaccination with CoronaVac and the COVID-19 infections among the health care workers in a university hospital and to determine the vaccine effectiveness against COVID-19 in a period when alpha variant was dominant. METHODS: This retrospective cohort study was conducted in a university hospital in Istanbul, Turkey employs 4067 health care workers. The follow-up period was defined as starting 14 days after receiving the second dose for fully vaccinated group. Health care workers were censored when have a positive PCR test result or at the end of the study. Unvaccinated health care workers were censored if they receive any COVID-19 vaccine doses. The incidence rate ratio and Cox regression were used to estimate the unadjusted and adjusted effectiveness of the vaccine. Findings: Seventy-one percent of the health care workers were fully vaccinated whereas 29% percent did not receive any doses. The incidence rate of SARS-CoV-2 infection was 133.7 vs 70.7 per 100.000 person-days in the unvaccinated and fully vaccinated groups, respectively. The unadjusted effectiveness against COVID-19 infection was 47% (95% CI 31–59%) whereas adjusted effectiveness was 39% (95% CI 20–64%). Interpretation: This real life study conducted in health care workers demonstrated that the effectiveness of two doses of the CoronaVac vaccine (39%) was lower than that determined in clinical trials. Due to reduce in protection over time or against variants, booster doses may be needed. Elsevier Ltd. 2022-04-20 2022-03-19 /pmc/articles/PMC8934134/ /pubmed/35317942 http://dx.doi.org/10.1016/j.vaccine.2022.03.032 Text en © 2022 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Can, Gunay Acar, Hazal Cansu Aydin, Sumeyye Nur Balkan, Ilker Inanc Karaali, Ridvan Budak, Beyhan Saltoglu, Nese Waning effectiveness of CoronaVac in real life: A retrospective cohort study in health care workers |
title | Waning effectiveness of CoronaVac in real life: A retrospective cohort study in health care workers |
title_full | Waning effectiveness of CoronaVac in real life: A retrospective cohort study in health care workers |
title_fullStr | Waning effectiveness of CoronaVac in real life: A retrospective cohort study in health care workers |
title_full_unstemmed | Waning effectiveness of CoronaVac in real life: A retrospective cohort study in health care workers |
title_short | Waning effectiveness of CoronaVac in real life: A retrospective cohort study in health care workers |
title_sort | waning effectiveness of coronavac in real life: a retrospective cohort study in health care workers |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934134/ https://www.ncbi.nlm.nih.gov/pubmed/35317942 http://dx.doi.org/10.1016/j.vaccine.2022.03.032 |
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