Progression-Free Survival of a Patient with Advanced Hepatocellular Carcinoma Treated with Adoptive Cell Therapy Using Natural Killer Cells: A Case Report

Adoptive cell therapy (ACT) is a promising treatment that is considered safe and efficient. Natural killer (NK) cells play an important role in the innate immune system and destroy target cells such as tumor cells without prior sensitization. Here, we report a 59-year-old man with advanced diffuse h...

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Autores principales: Hong, Guodai, Xie, Silun, Guo, Zikuan, Zhang, Diping, Ge, Sihai, Zhang, Suqin, Gao, Wenbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934175/
https://www.ncbi.nlm.nih.gov/pubmed/35313527
http://dx.doi.org/10.2147/OTT.S344707
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author Hong, Guodai
Xie, Silun
Guo, Zikuan
Zhang, Diping
Ge, Sihai
Zhang, Suqin
Gao, Wenbin
author_facet Hong, Guodai
Xie, Silun
Guo, Zikuan
Zhang, Diping
Ge, Sihai
Zhang, Suqin
Gao, Wenbin
author_sort Hong, Guodai
collection PubMed
description Adoptive cell therapy (ACT) is a promising treatment that is considered safe and efficient. Natural killer (NK) cells play an important role in the innate immune system and destroy target cells such as tumor cells without prior sensitization. Here, we report a 59-year-old man with advanced diffuse hepatocellular carcinoma (HCC) who underwent 17 courses of NK cell treatment from March 2017 to July 2018. Although he presented with progressive disease, his hydrothorax and ascites decreased, and his state of mind, appetite and quality of life were markedly improved after treatment versus at admission. To date, his survival time is >48 months. Here, we provide evidence that NK cell adoptive therapy has no adverse effects, enhances immune function, and improves the quality of life of patients with HCC.
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spelling pubmed-89341752022-03-20 Progression-Free Survival of a Patient with Advanced Hepatocellular Carcinoma Treated with Adoptive Cell Therapy Using Natural Killer Cells: A Case Report Hong, Guodai Xie, Silun Guo, Zikuan Zhang, Diping Ge, Sihai Zhang, Suqin Gao, Wenbin Onco Targets Ther Case Report Adoptive cell therapy (ACT) is a promising treatment that is considered safe and efficient. Natural killer (NK) cells play an important role in the innate immune system and destroy target cells such as tumor cells without prior sensitization. Here, we report a 59-year-old man with advanced diffuse hepatocellular carcinoma (HCC) who underwent 17 courses of NK cell treatment from March 2017 to July 2018. Although he presented with progressive disease, his hydrothorax and ascites decreased, and his state of mind, appetite and quality of life were markedly improved after treatment versus at admission. To date, his survival time is >48 months. Here, we provide evidence that NK cell adoptive therapy has no adverse effects, enhances immune function, and improves the quality of life of patients with HCC. Dove 2022-03-15 /pmc/articles/PMC8934175/ /pubmed/35313527 http://dx.doi.org/10.2147/OTT.S344707 Text en © 2022 Hong et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Case Report
Hong, Guodai
Xie, Silun
Guo, Zikuan
Zhang, Diping
Ge, Sihai
Zhang, Suqin
Gao, Wenbin
Progression-Free Survival of a Patient with Advanced Hepatocellular Carcinoma Treated with Adoptive Cell Therapy Using Natural Killer Cells: A Case Report
title Progression-Free Survival of a Patient with Advanced Hepatocellular Carcinoma Treated with Adoptive Cell Therapy Using Natural Killer Cells: A Case Report
title_full Progression-Free Survival of a Patient with Advanced Hepatocellular Carcinoma Treated with Adoptive Cell Therapy Using Natural Killer Cells: A Case Report
title_fullStr Progression-Free Survival of a Patient with Advanced Hepatocellular Carcinoma Treated with Adoptive Cell Therapy Using Natural Killer Cells: A Case Report
title_full_unstemmed Progression-Free Survival of a Patient with Advanced Hepatocellular Carcinoma Treated with Adoptive Cell Therapy Using Natural Killer Cells: A Case Report
title_short Progression-Free Survival of a Patient with Advanced Hepatocellular Carcinoma Treated with Adoptive Cell Therapy Using Natural Killer Cells: A Case Report
title_sort progression-free survival of a patient with advanced hepatocellular carcinoma treated with adoptive cell therapy using natural killer cells: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934175/
https://www.ncbi.nlm.nih.gov/pubmed/35313527
http://dx.doi.org/10.2147/OTT.S344707
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