HuR Promotes the Progression of Gastric Cancer through Mediating CDC5L Expression

METHODS: We performed qRT-PCR, cell cycle assay, cell migration, and mouse transplantation model analysis in our experiments. It has been clarified that HuR and microRNAs (miRNAs) have important interplays in the regulation of tumor progression. RESULTS: This study found microRNA-133b (miR-133b), as...

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Autores principales: Cui, Jing, Cao, Nanjing, Wang, Guochao, Wang, Fuhua, Yang, Bin, Wang, Jian, Lv, Yongqiang, Chen, Yunqing, Li, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934217/
https://www.ncbi.nlm.nih.gov/pubmed/35313568
http://dx.doi.org/10.1155/2022/5141927
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author Cui, Jing
Cao, Nanjing
Wang, Guochao
Wang, Fuhua
Yang, Bin
Wang, Jian
Lv, Yongqiang
Chen, Yunqing
Li, Feng
author_facet Cui, Jing
Cao, Nanjing
Wang, Guochao
Wang, Fuhua
Yang, Bin
Wang, Jian
Lv, Yongqiang
Chen, Yunqing
Li, Feng
author_sort Cui, Jing
collection PubMed
description METHODS: We performed qRT-PCR, cell cycle assay, cell migration, and mouse transplantation model analysis in our experiments. It has been clarified that HuR and microRNAs (miRNAs) have important interplays in the regulation of tumor progression. RESULTS: This study found microRNA-133b (miR-133b), as a HuR-sponged miRNA in GC cells. Downregulation of HuR can promote the expression of miR-133b and further affect the downstream cyclin CDC5L. The expressions of miR-133b were slightly lower in GC tissues than adjacent normal tissues. CONCLUSION: Our studies suggest that HuR and miR-133b are involved in the development and pathological process of GC cells.
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spelling pubmed-89342172022-03-20 HuR Promotes the Progression of Gastric Cancer through Mediating CDC5L Expression Cui, Jing Cao, Nanjing Wang, Guochao Wang, Fuhua Yang, Bin Wang, Jian Lv, Yongqiang Chen, Yunqing Li, Feng Dis Markers Research Article METHODS: We performed qRT-PCR, cell cycle assay, cell migration, and mouse transplantation model analysis in our experiments. It has been clarified that HuR and microRNAs (miRNAs) have important interplays in the regulation of tumor progression. RESULTS: This study found microRNA-133b (miR-133b), as a HuR-sponged miRNA in GC cells. Downregulation of HuR can promote the expression of miR-133b and further affect the downstream cyclin CDC5L. The expressions of miR-133b were slightly lower in GC tissues than adjacent normal tissues. CONCLUSION: Our studies suggest that HuR and miR-133b are involved in the development and pathological process of GC cells. Hindawi 2022-03-12 /pmc/articles/PMC8934217/ /pubmed/35313568 http://dx.doi.org/10.1155/2022/5141927 Text en Copyright © 2022 Jing Cui et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Cui, Jing
Cao, Nanjing
Wang, Guochao
Wang, Fuhua
Yang, Bin
Wang, Jian
Lv, Yongqiang
Chen, Yunqing
Li, Feng
HuR Promotes the Progression of Gastric Cancer through Mediating CDC5L Expression
title HuR Promotes the Progression of Gastric Cancer through Mediating CDC5L Expression
title_full HuR Promotes the Progression of Gastric Cancer through Mediating CDC5L Expression
title_fullStr HuR Promotes the Progression of Gastric Cancer through Mediating CDC5L Expression
title_full_unstemmed HuR Promotes the Progression of Gastric Cancer through Mediating CDC5L Expression
title_short HuR Promotes the Progression of Gastric Cancer through Mediating CDC5L Expression
title_sort hur promotes the progression of gastric cancer through mediating cdc5l expression
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934217/
https://www.ncbi.nlm.nih.gov/pubmed/35313568
http://dx.doi.org/10.1155/2022/5141927
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