A Case of Persistent Bacillus cereus Bacteremia Responding to a Combination of Vancomycin and Gentamicin

A 56-year-old woman with a history of connective tissue disease developed fever, and Bacillus cereus (B. cereus) was detected in blood cultures. Therefore, treatment with vancomycin (VCM) was initiated. Since her blood cultures persistently detected B. cereus despite peripheral intravenous catheter...

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Detalles Bibliográficos
Autores principales: Sasano, Hiroshi, Yoshizawa, Toshihiro, Suzuki, Mai, Fukui, Yukiko, Arakawa, Ryutarou, Tamura, Naoto, Naito, Toshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934234/
https://www.ncbi.nlm.nih.gov/pubmed/35313466
http://dx.doi.org/10.1155/2022/8725102
Descripción
Sumario:A 56-year-old woman with a history of connective tissue disease developed fever, and Bacillus cereus (B. cereus) was detected in blood cultures. Therefore, treatment with vancomycin (VCM) was initiated. Since her blood cultures persistently detected B. cereus despite peripheral intravenous catheter replacement and VCM treatment, concomitant treatment with gentamicin (GM) was started. Blood cultures then became negative. Persistent B. cereus bacteremia responded to combination therapy with VCM and GM. This combination therapy may increase the risk of developing renal dysfunction, but the risk can be mitigated by appropriate therapeutic drug monitoring (TDM) and dose adjustments to achieve successful treatment.

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