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A Case of Persistent Bacillus cereus Bacteremia Responding to a Combination of Vancomycin and Gentamicin

A 56-year-old woman with a history of connective tissue disease developed fever, and Bacillus cereus (B. cereus) was detected in blood cultures. Therefore, treatment with vancomycin (VCM) was initiated. Since her blood cultures persistently detected B. cereus despite peripheral intravenous catheter...

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Autores principales: Sasano, Hiroshi, Yoshizawa, Toshihiro, Suzuki, Mai, Fukui, Yukiko, Arakawa, Ryutarou, Tamura, Naoto, Naito, Toshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934234/
https://www.ncbi.nlm.nih.gov/pubmed/35313466
http://dx.doi.org/10.1155/2022/8725102
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author Sasano, Hiroshi
Yoshizawa, Toshihiro
Suzuki, Mai
Fukui, Yukiko
Arakawa, Ryutarou
Tamura, Naoto
Naito, Toshio
author_facet Sasano, Hiroshi
Yoshizawa, Toshihiro
Suzuki, Mai
Fukui, Yukiko
Arakawa, Ryutarou
Tamura, Naoto
Naito, Toshio
author_sort Sasano, Hiroshi
collection PubMed
description A 56-year-old woman with a history of connective tissue disease developed fever, and Bacillus cereus (B. cereus) was detected in blood cultures. Therefore, treatment with vancomycin (VCM) was initiated. Since her blood cultures persistently detected B. cereus despite peripheral intravenous catheter replacement and VCM treatment, concomitant treatment with gentamicin (GM) was started. Blood cultures then became negative. Persistent B. cereus bacteremia responded to combination therapy with VCM and GM. This combination therapy may increase the risk of developing renal dysfunction, but the risk can be mitigated by appropriate therapeutic drug monitoring (TDM) and dose adjustments to achieve successful treatment.
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spelling pubmed-89342342022-03-20 A Case of Persistent Bacillus cereus Bacteremia Responding to a Combination of Vancomycin and Gentamicin Sasano, Hiroshi Yoshizawa, Toshihiro Suzuki, Mai Fukui, Yukiko Arakawa, Ryutarou Tamura, Naoto Naito, Toshio Case Rep Infect Dis Case Report A 56-year-old woman with a history of connective tissue disease developed fever, and Bacillus cereus (B. cereus) was detected in blood cultures. Therefore, treatment with vancomycin (VCM) was initiated. Since her blood cultures persistently detected B. cereus despite peripheral intravenous catheter replacement and VCM treatment, concomitant treatment with gentamicin (GM) was started. Blood cultures then became negative. Persistent B. cereus bacteremia responded to combination therapy with VCM and GM. This combination therapy may increase the risk of developing renal dysfunction, but the risk can be mitigated by appropriate therapeutic drug monitoring (TDM) and dose adjustments to achieve successful treatment. Hindawi 2022-03-12 /pmc/articles/PMC8934234/ /pubmed/35313466 http://dx.doi.org/10.1155/2022/8725102 Text en Copyright © 2022 Hiroshi Sasano et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Sasano, Hiroshi
Yoshizawa, Toshihiro
Suzuki, Mai
Fukui, Yukiko
Arakawa, Ryutarou
Tamura, Naoto
Naito, Toshio
A Case of Persistent Bacillus cereus Bacteremia Responding to a Combination of Vancomycin and Gentamicin
title A Case of Persistent Bacillus cereus Bacteremia Responding to a Combination of Vancomycin and Gentamicin
title_full A Case of Persistent Bacillus cereus Bacteremia Responding to a Combination of Vancomycin and Gentamicin
title_fullStr A Case of Persistent Bacillus cereus Bacteremia Responding to a Combination of Vancomycin and Gentamicin
title_full_unstemmed A Case of Persistent Bacillus cereus Bacteremia Responding to a Combination of Vancomycin and Gentamicin
title_short A Case of Persistent Bacillus cereus Bacteremia Responding to a Combination of Vancomycin and Gentamicin
title_sort case of persistent bacillus cereus bacteremia responding to a combination of vancomycin and gentamicin
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934234/
https://www.ncbi.nlm.nih.gov/pubmed/35313466
http://dx.doi.org/10.1155/2022/8725102
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