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Bach2: A Key Regulator in Th2-Related Immune Cells and Th2 Immune Response

Th2 immune response is essential for providing protection against pathogens and orchestrating humoral immunity. However, excessive Th2 immune response leads to the pathogenesis of Th2 inflammation diseases, including asthma, allergic rhinitis, and atopic dermatitis. Emerging evidence suggest a criti...

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Detalles Bibliográficos
Autores principales: Liu, Guo, Liu, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934237/
https://www.ncbi.nlm.nih.gov/pubmed/35313725
http://dx.doi.org/10.1155/2022/2814510
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author Liu, Guo
Liu, Feng
author_facet Liu, Guo
Liu, Feng
author_sort Liu, Guo
collection PubMed
description Th2 immune response is essential for providing protection against pathogens and orchestrating humoral immunity. However, excessive Th2 immune response leads to the pathogenesis of Th2 inflammation diseases, including asthma, allergic rhinitis, and atopic dermatitis. Emerging evidence suggest a critical role of the transcription factor Bach2 in regulating Th2 immune responses. Bach2 serves as a super enhancer and transcriptional repressor to control the differentiation and maturation of Th2-related immune cells such as B cell lineages and T cell lineages. In B cells, Bach2 is required for every stage of B cell development and can delay the class switch recombination and antibody-producing plasma cell differentiation. In T cell lineages, Bach2 suppresses the CD4(+) T cell differentiation into Th2 cells, restrains Th2 cytokine production, and promotes the generation and function of regulatory T (Treg) cells to balance the immune activity. Furthermore, studies in various animal models show that Bach2 knockout animals spontaneously develop Th2 inflammation in the airway and gastrointestinal tract. Genome-wide association studies have identified various susceptibility loci of Bach2 which are linked with Th2 inflammatory diseases such as asthma and inflammatory bowel disease. Here, we discuss the critical role of Bach2 involved in the Th2 immune response and associated inflammatory diseases.
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spelling pubmed-89342372022-03-20 Bach2: A Key Regulator in Th2-Related Immune Cells and Th2 Immune Response Liu, Guo Liu, Feng J Immunol Res Review Article Th2 immune response is essential for providing protection against pathogens and orchestrating humoral immunity. However, excessive Th2 immune response leads to the pathogenesis of Th2 inflammation diseases, including asthma, allergic rhinitis, and atopic dermatitis. Emerging evidence suggest a critical role of the transcription factor Bach2 in regulating Th2 immune responses. Bach2 serves as a super enhancer and transcriptional repressor to control the differentiation and maturation of Th2-related immune cells such as B cell lineages and T cell lineages. In B cells, Bach2 is required for every stage of B cell development and can delay the class switch recombination and antibody-producing plasma cell differentiation. In T cell lineages, Bach2 suppresses the CD4(+) T cell differentiation into Th2 cells, restrains Th2 cytokine production, and promotes the generation and function of regulatory T (Treg) cells to balance the immune activity. Furthermore, studies in various animal models show that Bach2 knockout animals spontaneously develop Th2 inflammation in the airway and gastrointestinal tract. Genome-wide association studies have identified various susceptibility loci of Bach2 which are linked with Th2 inflammatory diseases such as asthma and inflammatory bowel disease. Here, we discuss the critical role of Bach2 involved in the Th2 immune response and associated inflammatory diseases. Hindawi 2022-03-12 /pmc/articles/PMC8934237/ /pubmed/35313725 http://dx.doi.org/10.1155/2022/2814510 Text en Copyright © 2022 Guo Liu and Feng Liu. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Liu, Guo
Liu, Feng
Bach2: A Key Regulator in Th2-Related Immune Cells and Th2 Immune Response
title Bach2: A Key Regulator in Th2-Related Immune Cells and Th2 Immune Response
title_full Bach2: A Key Regulator in Th2-Related Immune Cells and Th2 Immune Response
title_fullStr Bach2: A Key Regulator in Th2-Related Immune Cells and Th2 Immune Response
title_full_unstemmed Bach2: A Key Regulator in Th2-Related Immune Cells and Th2 Immune Response
title_short Bach2: A Key Regulator in Th2-Related Immune Cells and Th2 Immune Response
title_sort bach2: a key regulator in th2-related immune cells and th2 immune response
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934237/
https://www.ncbi.nlm.nih.gov/pubmed/35313725
http://dx.doi.org/10.1155/2022/2814510
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