A one-dimensional parameter-free model for carcinogenesis in gene expression space

A small portion of a tissue defines a microstate in gene expression space. Mutations, epigenetic events or external factors cause microstate displacements which are modeled by combining small independent gene expression variations and large Levy jumps, resulting from the collective variations of a s...

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Autores principales: Herrero, Roberto, Leon, Dario A., Gonzalez, Augusto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934350/
https://www.ncbi.nlm.nih.gov/pubmed/35306505
http://dx.doi.org/10.1038/s41598-022-08502-8
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author Herrero, Roberto
Leon, Dario A.
Gonzalez, Augusto
author_facet Herrero, Roberto
Leon, Dario A.
Gonzalez, Augusto
author_sort Herrero, Roberto
collection PubMed
description A small portion of a tissue defines a microstate in gene expression space. Mutations, epigenetic events or external factors cause microstate displacements which are modeled by combining small independent gene expression variations and large Levy jumps, resulting from the collective variations of a set of genes. The risk of cancer in a tissue is estimated as the microstate probability to transit from the normal to the tumor region in gene expression space. The formula coming from the contribution of large Levy jumps seems to provide a qualitatively correct description of the lifetime risk of cancer in 8 tissues, and reveals an interesting connection between the risk and the way the tissue is protected against infections.
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spelling pubmed-89343502022-03-28 A one-dimensional parameter-free model for carcinogenesis in gene expression space Herrero, Roberto Leon, Dario A. Gonzalez, Augusto Sci Rep Article A small portion of a tissue defines a microstate in gene expression space. Mutations, epigenetic events or external factors cause microstate displacements which are modeled by combining small independent gene expression variations and large Levy jumps, resulting from the collective variations of a set of genes. The risk of cancer in a tissue is estimated as the microstate probability to transit from the normal to the tumor region in gene expression space. The formula coming from the contribution of large Levy jumps seems to provide a qualitatively correct description of the lifetime risk of cancer in 8 tissues, and reveals an interesting connection between the risk and the way the tissue is protected against infections. Nature Publishing Group UK 2022-03-19 /pmc/articles/PMC8934350/ /pubmed/35306505 http://dx.doi.org/10.1038/s41598-022-08502-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Herrero, Roberto
Leon, Dario A.
Gonzalez, Augusto
A one-dimensional parameter-free model for carcinogenesis in gene expression space
title A one-dimensional parameter-free model for carcinogenesis in gene expression space
title_full A one-dimensional parameter-free model for carcinogenesis in gene expression space
title_fullStr A one-dimensional parameter-free model for carcinogenesis in gene expression space
title_full_unstemmed A one-dimensional parameter-free model for carcinogenesis in gene expression space
title_short A one-dimensional parameter-free model for carcinogenesis in gene expression space
title_sort one-dimensional parameter-free model for carcinogenesis in gene expression space
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934350/
https://www.ncbi.nlm.nih.gov/pubmed/35306505
http://dx.doi.org/10.1038/s41598-022-08502-8
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