Discovery and Optimization of Tau Targeted Protein Degraders Enabled by Patient Induced Pluripotent Stem Cells-Derived Neuronal Models of Tauopathy

Accumulation of misfolded, aggregating proteins concurrent with disease onset and progression is a hallmark of neurodegenerative proteinopathies. An important class of these are tauopathies, such as frontotemporal dementia (FTD) and Alzheimer’s disease (AD), associated with accumulation of aberrant...

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Detalles Bibliográficos
Autores principales: Silva, M. Catarina, Nandi, Ghata, Donovan, Katherine A., Cai, Quan, Berry, Bethany C., Nowak, Radoslaw P., Fischer, Eric S., Gray, Nathanael S., Ferguson, Fleur M., Haggarty, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934437/
https://www.ncbi.nlm.nih.gov/pubmed/35317195
http://dx.doi.org/10.3389/fncel.2022.801179

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