Cargando…
Successful treatment with proton beam therapy for a solitary sternal metastasis of breast cancer: a case report
BACKGROUND: Breast cancer infrequently metastasizes to the sternum as solitary metastasis. We experienced successful treatment with proton beam therapy for a case of sternal metastasis of breast cancer. This case demonstrates for the first time the role of proton therapy in the treatment of oligomet...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934454/ https://www.ncbi.nlm.nih.gov/pubmed/35305684 http://dx.doi.org/10.1186/s13256-022-03335-5 |
_version_ | 1784671852763807744 |
---|---|
author | Ishikawa, Yojiro Suzuki, Motohisa Yamaguchi, Hisashi Seto, Ichiro Machida, Masanori Takagawa, Yoshiaki Jingu, Keiichi Kikuchi, Yasuyuki Murakami, Masao |
author_facet | Ishikawa, Yojiro Suzuki, Motohisa Yamaguchi, Hisashi Seto, Ichiro Machida, Masanori Takagawa, Yoshiaki Jingu, Keiichi Kikuchi, Yasuyuki Murakami, Masao |
author_sort | Ishikawa, Yojiro |
collection | PubMed |
description | BACKGROUND: Breast cancer infrequently metastasizes to the sternum as solitary metastasis. We experienced successful treatment with proton beam therapy for a case of sternal metastasis of breast cancer. This case demonstrates for the first time the role of proton therapy in the treatment of oligometastatic sternal metastasis with limited tolerance of normal tissue due to previous photon irradiation. CASE PRESENTATION: A 40-year-old Japanese female presented with lumpiness in her left breast. The patient was diagnosed with breast cancer (cT1N0M0, cStage IA) and underwent partial mastectomy with axillary lymph node dissection. After the mastectomy, the patient received radiation therapy with 50 Gy in 25 fractions for initial irradiation of the left breast. After the initial irradiation of 50 Gy, the patient received 10 Gy in five fractions of a sequential boost for the tumor bed to a total dose of 60 Gy. Although the patient was administered tamoxifen after radiation therapy, solitary sternal metastasis occurred 6 months after radiation therapy. She refused chemotherapy and requested proton beam therapy for her sternal metastasis. The daily proton beam therapy fractions were 2.5 relative biological effectiveness, receiving a total dose of 70 Gy relative biological effectiveness. An acute side effect of grade 2 dermatitis according to the National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0. occurred during proton beam therapy, but there was no acute or late complication of more than grade 3. At 3 years after proton beam therapy, the patient remains in complete remission without surgery or chemotherapy. DISCUSSION AND CONCLUSION: Proton beam therapy for solitary sternal metastasis of breast cancer is considered to be a therapeutic option. |
format | Online Article Text |
id | pubmed-8934454 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-89344542022-03-23 Successful treatment with proton beam therapy for a solitary sternal metastasis of breast cancer: a case report Ishikawa, Yojiro Suzuki, Motohisa Yamaguchi, Hisashi Seto, Ichiro Machida, Masanori Takagawa, Yoshiaki Jingu, Keiichi Kikuchi, Yasuyuki Murakami, Masao J Med Case Rep Case Report BACKGROUND: Breast cancer infrequently metastasizes to the sternum as solitary metastasis. We experienced successful treatment with proton beam therapy for a case of sternal metastasis of breast cancer. This case demonstrates for the first time the role of proton therapy in the treatment of oligometastatic sternal metastasis with limited tolerance of normal tissue due to previous photon irradiation. CASE PRESENTATION: A 40-year-old Japanese female presented with lumpiness in her left breast. The patient was diagnosed with breast cancer (cT1N0M0, cStage IA) and underwent partial mastectomy with axillary lymph node dissection. After the mastectomy, the patient received radiation therapy with 50 Gy in 25 fractions for initial irradiation of the left breast. After the initial irradiation of 50 Gy, the patient received 10 Gy in five fractions of a sequential boost for the tumor bed to a total dose of 60 Gy. Although the patient was administered tamoxifen after radiation therapy, solitary sternal metastasis occurred 6 months after radiation therapy. She refused chemotherapy and requested proton beam therapy for her sternal metastasis. The daily proton beam therapy fractions were 2.5 relative biological effectiveness, receiving a total dose of 70 Gy relative biological effectiveness. An acute side effect of grade 2 dermatitis according to the National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0. occurred during proton beam therapy, but there was no acute or late complication of more than grade 3. At 3 years after proton beam therapy, the patient remains in complete remission without surgery or chemotherapy. DISCUSSION AND CONCLUSION: Proton beam therapy for solitary sternal metastasis of breast cancer is considered to be a therapeutic option. BioMed Central 2022-03-20 /pmc/articles/PMC8934454/ /pubmed/35305684 http://dx.doi.org/10.1186/s13256-022-03335-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Case Report Ishikawa, Yojiro Suzuki, Motohisa Yamaguchi, Hisashi Seto, Ichiro Machida, Masanori Takagawa, Yoshiaki Jingu, Keiichi Kikuchi, Yasuyuki Murakami, Masao Successful treatment with proton beam therapy for a solitary sternal metastasis of breast cancer: a case report |
title | Successful treatment with proton beam therapy for a solitary sternal metastasis of breast cancer: a case report |
title_full | Successful treatment with proton beam therapy for a solitary sternal metastasis of breast cancer: a case report |
title_fullStr | Successful treatment with proton beam therapy for a solitary sternal metastasis of breast cancer: a case report |
title_full_unstemmed | Successful treatment with proton beam therapy for a solitary sternal metastasis of breast cancer: a case report |
title_short | Successful treatment with proton beam therapy for a solitary sternal metastasis of breast cancer: a case report |
title_sort | successful treatment with proton beam therapy for a solitary sternal metastasis of breast cancer: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934454/ https://www.ncbi.nlm.nih.gov/pubmed/35305684 http://dx.doi.org/10.1186/s13256-022-03335-5 |
work_keys_str_mv | AT ishikawayojiro successfultreatmentwithprotonbeamtherapyforasolitarysternalmetastasisofbreastcanceracasereport AT suzukimotohisa successfultreatmentwithprotonbeamtherapyforasolitarysternalmetastasisofbreastcanceracasereport AT yamaguchihisashi successfultreatmentwithprotonbeamtherapyforasolitarysternalmetastasisofbreastcanceracasereport AT setoichiro successfultreatmentwithprotonbeamtherapyforasolitarysternalmetastasisofbreastcanceracasereport AT machidamasanori successfultreatmentwithprotonbeamtherapyforasolitarysternalmetastasisofbreastcanceracasereport AT takagawayoshiaki successfultreatmentwithprotonbeamtherapyforasolitarysternalmetastasisofbreastcanceracasereport AT jingukeiichi successfultreatmentwithprotonbeamtherapyforasolitarysternalmetastasisofbreastcanceracasereport AT kikuchiyasuyuki successfultreatmentwithprotonbeamtherapyforasolitarysternalmetastasisofbreastcanceracasereport AT murakamimasao successfultreatmentwithprotonbeamtherapyforasolitarysternalmetastasisofbreastcanceracasereport |