Combination of artesunate and WNT974 induces KRAS protein degradation by upregulating E3 ligase ANACP2 and β-TrCP in the ubiquitin–proteasome pathway

BACKGROUND: KRAS mutation is one of the dominant gene mutations in colorectal cancer (CRC). Up to present, targeting KRAS for CRC treatment remains a clinical challenge. WNT974 (LGK974) is a porcupine inhibitor that interferes Wnt signaling pathway. Artesunate (ART) is a water-soluble semi-synthetic...

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Detalles Bibliográficos
Autores principales: Gong, Rui-Hong, Chen, Minting, Huang, Chunhua, Wong, Hoi Leong Xavier, Kwan, Hiu Yee, Bian, Zhaoxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934478/
https://www.ncbi.nlm.nih.gov/pubmed/35305671
http://dx.doi.org/10.1186/s12964-022-00834-2

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