Transcriptomic and genomic studies classify NKL54 as a histone deacetylase inhibitor with indirect influence on MEF2-dependent transcription

In leiomyosarcoma class IIa HDACs (histone deacetylases) bind MEF2 and convert these transcription factors into repressors to sustain proliferation. Disruption of this complex with small molecules should antagonize cancer growth. NKL54, a PAOA (pimeloylanilide o-aminoanilide) derivative, binds a hyd...

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Detalles Bibliográficos
Autores principales: Minisini, Martina, Di Giorgio, Eros, Kerschbamer, Emanuela, Dalla, Emiliano, Faggiani, Massimo, Franforte, Elisa, Meyer-Almes, Franz-Josef, Ragno, Rino, Antonini, Lorenzo, Mai, Antonello, Fiorentino, Francesco, Rotili, Dante, Chinellato, Monica, Perin, Stefano, Cendron, Laura, Weichenberger, Christian X, Angelini, Alessandro, Brancolini, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934631/
https://www.ncbi.nlm.nih.gov/pubmed/35150567
http://dx.doi.org/10.1093/nar/gkac081

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